Immunotherapy for Recurrent Spontaneous Abortion

  • Carolyn B. Coulam
Part of the Serono Symposia, USA book series (SERONOSYMP)


Recurrent spontaneous abortion (RSA) is a significant health problem affecting 2%–5% of reproducing couples (1). Although genetic, anatomic, and hormonal factors have been implicated in the etiology of RSA, a sizable proportion remains unexplained (2). An immunologic cause has been suggested for more than 80% of otherwise unexplained RSAs (3). Immunotherapy in various forms has been proposed as a treatment for these couples (4–12).


Seminal Plasma Pregnancy Loss Live Birth Rate Recurrent Pregnancy Loss Recurrent Spontaneous Abortion 
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© Springer-Verlag New York, Inc. 1994

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  • Carolyn B. Coulam

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