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Endometriosis pp 257–266Cite as

Adenomyosis

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Abstract

Since Rokitansky described adenomyosis in 1860, there has been little progress in understanding this condition. Incidence, pathogenesis, and pathophysiology still remain unclear. As endometriosis, it is an ectopic presence of endometrium (Fig. 26.1). Sometimes the clinical features can overlap, and frequently the two pathologies coexist. Hysterectomy has been the traditional method for treatment. This chapter provides a review of the literature and evaluates procedures that might be used for making an accurate diagnosis and for treating the disease in a noninvasive way.

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References

  1. Hendrickson MR, Kempson RL. Non-neoplastic conditions of the endometrium and uterine serosa. In Fox H, ed. Haines and Taylor Obstetrical and Gynecological Pathology, 3rd ed. New York, Churchill Livingstone, 1987, pp 405–410.

    Google Scholar 

  2. Novak ER, Woodruf JD. Novak’s Gynaecologic and Obstetric Pathology. Philadelphia, WB Saunders Co., 1979, pp 280–290.

    Google Scholar 

  3. Tindall VR. Jeffcoat Principles of Gynaecology, 5th ed. London: Butterworths, 1987, pp 360–361.

    Google Scholar 

  4. Benson RC, Sneeden VD. Adenomyosis: a reappraisal of symptomatology. Am J Obstet Gynecol 1958;76:1044–1061.

    PubMed  CAS  Google Scholar 

  5. Sakamoto A. Subserosal adenomyosis: a possible variant of pelvic endometriosis. Am J Obstet Gynecol 1991;165: 198–201.

    PubMed  CAS  Google Scholar 

  6. Javert CT. Observations on the pathology and spread of endometriosis based on the theory of benign metastasis. Am J Obstet Gynecol 1951;62:477–487.

    PubMed  CAS  Google Scholar 

  7. Azziz R. Adenomyosis: Current Perspectives. Obstetrics and Gynecology Clinics of North America 1989;16:221–235.

    PubMed  CAS  Google Scholar 

  8. Bird CC, McElin TW, Manalo-Estrella P. The elusive adenomyosis of the uterus. Am J Obstet Gynecol 1972; 112:583–593.

    PubMed  CAS  Google Scholar 

  9. Molitor JJ. Adenomyosis: a clinical and pathological appraisal. Am J Obstet Gynecol 1971;110:275–84.

    PubMed  CAS  Google Scholar 

  10. Nelson JR, Corson SL. Long-term management of adenomyosis with a gonadotropin-releasing hormone agonist: a case report. Fertil Steril 1993;59:441–443.

    PubMed  CAS  Google Scholar 

  11. McCausland AM. Hysteroscopic myometrial biopsy: its use in diagnosing adenomyosis and its clinical application. Am J Obstet Gynecol 1992;166:1619–1628.

    PubMed  CAS  Google Scholar 

  12. Owolabi TO, Stickler RC. Adenomyosis: a neglected diagnosis. Obstet Gynecol 1977;50:424–430.

    PubMed  CAS  Google Scholar 

  13. Frazer JS, McCarron G, Maikham R, et al. Measured menstrual blood loss in women with menorrhagia associated with pelvic disease or coagulation disorder. Obstet Gynecol 1986;69:630–635.

    Google Scholar 

  14. Koike H, Egana H, Ohtuka T, et al. Eicosanaids production in endometriosis. Prostaglandins Leukotines and Essential Fatty Acids 1992;45:313–317.

    Article  CAS  Google Scholar 

  15. Nishida M. Relationship between the onset of dysmenorrhea and histologic findings in adenomyosis. Am J Obstet Gynecol 1991;165:229–231.

    PubMed  CAS  Google Scholar 

  16. Koike H, Egana H, Ohtuka T, et al. Correlation between dysmenorrheic severity and prostaglandin production in women with endometriosis. Prostaglandins Leukotines and Essential Fatty Acids 1992;46:133–137.

    Article  CAS  Google Scholar 

  17. Jen SW, Lim-Tan SK, Wee D, et al. The clinical significance of adenomyosis and its relation to fertility. In Advances in fertility and sterility series, volume 5. London, The Parthenon Publishing Group, 1987, pp 207–212.

    Google Scholar 

  18. Walsh JW, Taylor KJM, Rosenfield AT. Gray scale ultrasonography in the diagnosis of endometriosis and endometriosis. Am J Radiol 1979;132:87–90.

    CAS  Google Scholar 

  19. Buli CM, Kasnar V, Dukovic I. Use of ultrasound in the diagnosis of genital endometriosis. Jugoslav Ginekol Perinatal 1986;26:33–38.

    Google Scholar 

  20. Bohlman ME, Ensor RE, Sanders RC. Sonographic findings in adenomyosis of the uterus. Am J Radiol 1987; 148:765–766.

    CAS  Google Scholar 

  21. Siedler D, Laing FC, Jeffrey RB. Uterine adenomyosis: a difficult sonographic diagnosis. J Ultrasound Med 1987; 6:345–349.

    PubMed  CAS  Google Scholar 

  22. Fedele L, Bianchi S, Dorta M, et al. Transvaginal ultrasonography in the diagnosis of diffuse adenomyosis. Fertil Steril 1992;58:94–97.

    PubMed  CAS  Google Scholar 

  23. McCarthy S. Gynecologic applications of MRI. Critical Reviews in Diagnostic Imaging 1990;31:2,263:281.

    Google Scholar 

  24. Hricak H, Finck S, Honda G, et al. MR imaging in the evaluation of benign uterine masses: value of gadopente-tate dimeglumine-enhanced T1-weighted images. Am J Radiol 1992;158:1043–1050.

    CAS  Google Scholar 

  25. Hricak H, Cannagton BM. MRI of the pelvis (a text atlas). Martin Dunitz Ltd., 1991, pp 100–101.

    Google Scholar 

  26. Togashi K, Ozasa H, Konishi I, et al. Enlarged uterus: differentiation between adenomyosis and leiomyoma with MR imaging. Radiology 1989;171:531–534.

    PubMed  CAS  Google Scholar 

  27. Mark AS, Hricak H, Heinrichs LW, et al. Adenomyosis and leiomyoma: differential diagnosis with MR imaging. Radiology 1987;163:527–529.

    PubMed  CAS  Google Scholar 

  28. Hunt RB, Siegler AM. Hysterosalpingography: Techniques and Interpretation. Chicago, Year Book Medical Publishers, Inc., 1990, pp 75–77.

    Google Scholar 

  29. Winfield AC, Wentz AC. The uterine cavity in diagnostic imaging in infertility. Baltimore, Williams & Wilkins, 1992, pp 112–115.

    Google Scholar 

  30. Nunley MC, Bateman BC, Kitchin JD, et al. Intravasation during hystersalpingography using oil base contrast medium. Obstet Gynecol 1987;70:309–312.

    PubMed  Google Scholar 

  31. Hirata JD, Moghissi KS, Ginsburg KA. Pregnancy after medical therapy of adenomyosis with a gonadotropin-releasing hormone agonist. Fertil Steril 1993;59:444–445.

    PubMed  CAS  Google Scholar 

  32. Bischof P, Zseng L, Brioschi PA, et al. Cancer antigen 125 is produced by human endometrial stromal cells. Hum Reprod 1986;1:423–426.

    PubMed  CAS  Google Scholar 

  33. Weintraub J, Bischof P, Zseng L, et al. Ca-125 is an excretory product of human endometrial glands. Biol Reprod 1990;42:721–726.

    Article  PubMed  CAS  Google Scholar 

  34. Jacobs IJ, Fay TN, Stabile I, et al. The distribution of Ca-125 in the reproductive tract of pregnant and non-pregnant women. Br J Obstet Gynecol 1988;95:1190–1194.

    Article  CAS  Google Scholar 

  35. Kabawat SE, Bast RC, Bhan AK, et al. Tissue distribution of a coelomic epithelium related antigen recognized by the monoclonal antibody OC 125. Int Gynecol Pathol 1983;2:275–285.

    Article  CAS  Google Scholar 

  36. Kijima S, Takahashi K, Kitao M. Expression of Ca-125 in adenomyosis (with 1 color plate). Gynecol Obstet Invest 1987;23:122–123.

    Article  PubMed  CAS  Google Scholar 

  37. Ida W, Kobayashi H, Naito Y. An in vitro study on the mechanism of Ca-125 production of endometrial cells—comparison of ectopic and heterotopic endometrium. Nippon-Somka-Fiyinka-Gukhai-Zasshi 1990; 42:1161–1167.

    CAS  Google Scholar 

  38. Kobayashi H, Ida W, Teiao T, et al. Qualitative assessment and characterization of Ca-125 antigen produced from human endometrial epithelial cells. Nippon-Somka-Fiyinka-Gukhai-Zasshi 1990;44:303–309.

    Google Scholar 

  39. Takahashi K, Kijima S, Yoshino K, et al. Differential diagnosis between leiomyomata uteri and adenomyosis using Ca-125 as a new tumor marker of ovarian carinoma. Acta Obstet Gynecol Jap 1985;37:591–595.

    CAS  Google Scholar 

  40. Halila H, Suikkari AM, Seppala M. The effect of hysterectomy on serum Ca-125 levels in patients with adenomyosis and uterine fibroids. Hum Reprod 1987;2:265–266.

    PubMed  CAS  Google Scholar 

  41. Cullen TS. Adenomyoma of the uterus. Philadelphia, WB Saunders Co., 1908.

    Google Scholar 

  42. Lewinski H, Esnge LA. The elusive adenomyosis of the uterus. Am J Obstet Gynecol 1962;83:1541–1555.

    Google Scholar 

  43. von Recklinghausen F. Die Adenomyose und cystadenoma den Uterus und Zuberwandung: ihne Abkunft von Resten des Wolfischen Korpers. Berlin: August Hirschwald, 1896.

    Google Scholar 

  44. Mori T, Nagasana H. Mechanisms of development of prolactin-induced adenomyosis in mice. Acta Anat 1983; 116:46–54.

    Article  PubMed  CAS  Google Scholar 

  45. Huseby RA, Soares MJ, Talamantis F. Ectopic pituitary grafts in mice: hormone levels, effects on fertility, and its development of adenomyosis uteri, prolactinomas, and mammary carcinomas. Endocrinology 1985;116:1440–1448.

    Article  PubMed  CAS  Google Scholar 

  46. Sakamoto S, Mori T, Singtripop T, et al. Increase of DNA synthesis in uterine adenomyosis in mice with ectopic pituitary isograft. Acta Anat 1992;145:162–166.

    Article  PubMed  CAS  Google Scholar 

  47. Singtripop T, Mori T, Kynnnpark M, et al. Development of uterine adenomyosis after treatment with dopamine antagonist in mice. Life Science 1991;49:201–206.

    Article  CAS  Google Scholar 

  48. Horrobin DF, Lipton A, Muiruri KL, et al. An inhibitory effect of prolactin on the response of rat myometrium to oxytocin. Experienta 1973;29:109–110.

    Article  CAS  Google Scholar 

  49. Mori T, Nagasana H. Alteration of the development of mammary hyperplastic alveolar nodules and uterine adenomyosis in SHN mice by different schedules of treatment with CB-154. Acta Endocrinologica 1984;107: 245–249.

    PubMed  CAS  Google Scholar 

  50. Mori T, Ohta Y, Nagasawa H. Ultrastructural changes in uterine myometrium of mice with experimentally-induced adenomyosis. Experientia 1984;40:1385–1387.

    Article  PubMed  CAS  Google Scholar 

  51. Mati JKG, Mugambi M, Muriuki PB, et al. Effect of prolactin on isolated rabbit myometrium. J Endocr 1974; 60:379–380.

    Article  PubMed  CAS  Google Scholar 

  52. Lipton A, Leah J, Parkington HC. Effects of ovarian steroids and prolactin on the contractibility and sodium pomp site density of guinea-pig myometrium. J Endocr 1978;77:43–48.

    Article  PubMed  CAS  Google Scholar 

  53. Armstrong DT, King ER. Uterine progesteron metabolism and progestational response: effects of estrogens and prolactin. Endocrinology 1971;89:191–197.

    Article  PubMed  CAS  Google Scholar 

  54. Lipschultz A, Iglesias R, Panasevich V, et al. Pathological changes in the uterus of mice with the prolonged administration of progesteron and 19-m-contraceptives. Br J Cancer 1967;21:160–165.

    Article  Google Scholar 

  55. Lacassagne A. Modifications progressives de l’uterus de la souris sous l’action prolongée de l’oestrogène. CR Séances Soc Biol 1935;120:1156–1158.

    CAS  Google Scholar 

  56. Mori T, Singtripop T, Kawashima S. Animal models of uterine adenomyosis: is prolactin a potent inducer of adenomyosis in mice? Am J Obstet Gynecol 1991;165: 232–235.

    PubMed  CAS  Google Scholar 

  57. Walker BE. Uterine tumors in old female mice exposed prenatally to diethylstilbestrol. J Natl Cancer Inst 1983; 70:477–484.

    PubMed  CAS  Google Scholar 

  58. Mori T. Abnormalities in the reproductive system of aged mice after neonatal estradiol exposure. J Endocrinol Invest 1986;9:397–402.

    PubMed  CAS  Google Scholar 

  59. Ostrander PL, Mills KT, Bern HA. Long-term responses of the mose uterus to later sex hormone exposure. J Natl Cancer Inst. 1983;74:121–135.

    Google Scholar 

  60. Huseby RA, Thurlow S. Effets to prenatal exposure of mice to “low-dose” diethylstilbestrol and the development of adenomyosis associated with evidence of hyperpro-lactinemia. Am J Obstet Gynecol 1982;144:939–949.

    PubMed  CAS  Google Scholar 

  61. Tamaya T, Motoyama T, Ohono Y. Steroid receptor levels and histology of endometriosis and adenomyosis. Fertil Steril 1979;31:396–400.

    PubMed  CAS  Google Scholar 

  62. Van der Walt LA, Sanfilippo JS, Siegel JC, et al. Estrogen and progestin receptors in human uterus: reference ranges of clinical conditions. Clin Physiol Biochem 1986;4:217–220.

    PubMed  Google Scholar 

  63. Ota H, Maki M. Content of immunoglobulin G and complement components C3 and C4 in endometriotic tissue or endometrium in women with adenomyosis or endometriosis. Med Sci Res 1990;18:727–728.

    Google Scholar 

  64. Ota H, Maki M. Evaluation of autoantibody and Ca-125 in the diagnosis of endometriosis or adenomyosis. Med Sci Res 1990;18:309–310.

    Google Scholar 

  65. Ota H, Igarashi S, Maki M. Distribution of tissue macrophages in uterine muscle layers in patients with adenomyosis. Med Sci Res 1991;19:473–474.

    Google Scholar 

  66. Woodruff JD, Erozam YS, Genadry R. Adenocarcinoma arising in adenomyosis detected by atypical cytology. Obstet Gynecol 1986;67:145–148.

    PubMed  CAS  Google Scholar 

  67. Hayata T. Ultrastructural study of glandular epithelium in adenomyosis in comparison with those of proliferative endometrium and well-differentiated endometrial cancer. Am J Obstet Gynecol 1991;165:225–228.

    PubMed  CAS  Google Scholar 

  68. Giammalvo JJ, Kaplan K. The incidence of endometriosis interna in 120 cases of carcinoma of the endometrium. Am J Obstet Gynecol 1958;75:161–165.

    PubMed  CAS  Google Scholar 

  69. Marcus CC. Relationship of adenomyosis uteri to endometrial hyperplasia and endometrial carcinoma. Am J Obstet Gynecol 1961;82:408–16.

    PubMed  CAS  Google Scholar 

  70. Hayata T, Korwashima Y. Clinicopathologic study of eight cases of uterine body cancers associated with endometriosis interna (uterine adenomyosis). Am J Obstet Gynecol 1987;156:663–666.

    PubMed  CAS  Google Scholar 

  71. Greenwood SM. The relation of adenomyosis uteri to coexistent endometrial carcinoma and endometrial hyperplasia. Obstet Gynecol 1976;48:68–72.

    PubMed  CAS  Google Scholar 

  72. Johnson RV, Roddick JW Jr. Incidence of adenomyosis in patients with endometrial adenocarcinoma. A study of 100 patients. Am J Obstet Gynecol 1961;81:268–271.

    PubMed  CAS  Google Scholar 

  73. Hernandez E, Woodruff JF. Endometrial adenocarcinoma arising in adenomyosis. Am J Obstet Gynecol 1980;138: 827–832.

    PubMed  CAS  Google Scholar 

  74. Jacques SM, Lawrence DW. Endometrial adenocarcinoma with variable-level myometrial involvement limited to adenomyosis: a clinicopathologic study of 23 cases. Gynecol Oncol 1990;37:401–407.

    Article  PubMed  CAS  Google Scholar 

  75. Hall JB, Young RH, Nelson JH. The prognostic significance of adenomyosis in endometrial carcinoma. Gynecol Oncol 1984;17:32–40.

    Article  PubMed  CAS  Google Scholar 

  76. Grow DR, Filer RB. Treatment of adenomyosis with long-term GnRH analogues: a case report. Obstet Gynecol 1991;78:538–539.

    PubMed  CAS  Google Scholar 

  77. Igarashi M. A new therapy for pelvic endometriosis and uterine adenomyosis: local effect of vaginal and intrauterine danazol application. Asia Oceania J Obstet Gynecol 1990;16:1–12.

    Article  CAS  Google Scholar 

  78. Singtripop T, Mori T, Sakamoto S, et al. Suppression of the development of uterine adenomyosis by danazol treatment in mice. Life Sci 51:1119–1125.

    Google Scholar 

  79. Ota H, Maki M, Shidara Y, et al. Effects of danazol at the immunologic level in patients with adenomyosis with special reference to autoantibodies: a multi-centre cooperative study. Am J Obstet Gynecol 1992;167:481–486.

    PubMed  CAS  Google Scholar 

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Authors
  1. Paul Devroey
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  2. Guy Verhulst
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Mercer University School of Medicine, Macon, GA, 31207, USA

    Camran R. Nezhat M.D. , Farr R. Nezhat M.D.  & Ceana H. Nezhat M.D. ,  & 

  2. Department of Obstetrics and Gynecology, Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Camran R. Nezhat M.D. , Farr R. Nezhat M.D.  & Ceana H. Nezhat M.D. ,  & 

  3. Center for Special Pelvic Surgery, Atlanta, GA, 30342, USA

    Camran R. Nezhat M.D. , Farr R. Nezhat M.D.  & Ceana H. Nezhat M.D. ,  & 

  4. Center for Special Pelvic Surgery, Palo Alto, CA, 94304, USA

    Camran R. Nezhat M.D. , Farr R. Nezhat M.D.  & Ceana H. Nezhat M.D. ,  & 

  5. Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, 27514, USA

    Gary S. Berger M.D.

  6. Department of Maternal and Child Health, University of North Carolina School of Public Health, Chapel Hill, NC, 27514, USA

    Gary S. Berger M.D.

  7. Chapel Hill Fertility Center, Chapel Hill, NC, 27514, USA

    Gary S. Berger M.D.

  8. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, 77054, USA

    Veasy C. Buttram Jr. M.D.

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© 1995 Springer-Verlag New York, Inc.

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Devroey, P., Verhulst, G. (1995). Adenomyosis. In: Nezhat, C.R., Berger, G.S., Nezhat, F.R., Buttram, V.C., Nezhat, C.H. (eds) Endometriosis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8404-5_26

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  • DOI: https://doi.org/10.1007/978-1-4613-8404-5_26

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  • Online ISBN: 978-1-4613-8404-5

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