Endometriosis pp 245-255 | Cite as

Treatment of Infertility Associated With Endometriosis

  • Deborah Metzger


Despite many years of investigations and clinical trials, treatment of endometriosis-associated infertility remains controversial. A plethora of therapeutic approaches have been suggested including expectant management, medical intervention, major conservative surgery, and laparoscopic resection.1


Pregnancy Rate Obstet Gynecol Peritoneal Fluid Clomiphene Citrate Infertile Woman 
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  1. 1.
    Olive DL, Haney AF. Endometriosis-associated infertility: A critical review of therapeutic approaches. Obstet Gynecol Surv 1986;41:538.PubMedGoogle Scholar
  2. 2.
    Metzger DA, Haney AF. Endometriosis: Etiology and pathophysiology of infertility. Clin Obstet Gynecol 1988; 31:801.PubMedGoogle Scholar
  3. 3.
    Metzger DA, Luciano AA. Hormonal therapy of endometriosis. Obstet Gynecol Clin NA 1989;16:105.Google Scholar
  4. 4.
    Evers JLH. The second-look laparoscopy for evaluation of the results of medical treatment of endometriosis should not be performed during ovarian suppression. Fertil Steril 1987;47:502–504.PubMedGoogle Scholar
  5. 5.
    Nisolle-Pochet M, Casanas-Roux F, Donnez J. Histologic study of ovarian endometriosis after hormonal therapy. Fertil Steril 1988;49:423.PubMedGoogle Scholar
  6. 6.
    Olive DL, Martin DC. Treatment of endometriosis-associated infertility with CO2 laser laparoscopy: the use of one- and two-parameter exponential models. Fertil Steril 1987;48:18.PubMedGoogle Scholar
  7. 7.
    Strathy JH, Molgaard CA, Coulam CB, et al. Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril 1982;38:66.Google Scholar
  8. 8.
    Tulandi T, Mouchawar M. Treatment-dependent and treatment-independent pregnancy in women with minimal and mild endometriosis. Fertil Steril 1991;56:790.PubMedGoogle Scholar
  9. 9.
    Grant A. Additional sterility factors in endometriosis. Fertil Steril 1966;17:514.PubMedGoogle Scholar
  10. 10.
    Gast MJ, Tobler R, Strickler RC, et al. Laser vaporization of endometriosis in an infertile population: the role of complicating infertility factors. Fertil Steril 1988;49:32.PubMedGoogle Scholar
  11. 11.
    Murphy AA, Schlaff WD, Hassiakos D, et al. Laparoscopic cautery in the treatment of endometriosis-related infertility. Fertil Steril 1991;55:246.PubMedGoogle Scholar
  12. 12.
    Portuondo JA, Eschanojauregui AD, Herran C. Early conception in patients with untreated mild endometriosis. Fertil Steril 1983;39:22.PubMedGoogle Scholar
  13. 13.
    Jansen RPS. Minimal endometriosis and reduced fecun-dability: prospective evidence from an artificial insemination by donor program. Fertil Steril 1986;46:141.PubMedGoogle Scholar
  14. 14.
    Jones HW, Anibal AA, Andrews MC, et al. Three years of in vitro fertilization at Norfolk. Fertil Steril 1984; 42:826.PubMedGoogle Scholar
  15. 15.
    Dodson WC, Whitesides DB, Hughes CL Jr, et al. Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization. Fertil Steril 1987;48:441.PubMedGoogle Scholar
  16. 16.
    Chaffkin LM, Nulsen JC, Luciano AA, et al. A comparative analysis of the cycle fecundity rates associated with combined human menopausal gonadotropin (hMG) and intrauterine insemination (IUI) versus either hMG or IUI alone. Fertil Steril 1991;55:252.PubMedGoogle Scholar
  17. 17.
    Luciano AA, Marana R, Kratka S, et al. Ovarian function after incision of the ovary by scalpel, CO2 laser and microelectrode. Fertil Steril 1991;56:349.PubMedGoogle Scholar
  18. 18.
    Fortier KJ, Haney AF. The pathologic spectrum of uterotubal unction obstruction. Obstet Gynecol 1985; 65:93.PubMedGoogle Scholar
  19. 19.
    Moon YS, Leung PCS, Yuen BH, et al. Prostaglandin F in human endometriotic tissue. Am J Obstet Gynecol 1981;141:344.PubMedGoogle Scholar
  20. 20.
    Badawy SZA, Marshall L, Gabal AA, et al. The concentration of 13, 14-dihydro-15-keto prostaglandin F2 and prostaglandin E2 in peritoneal fluid of infertile patients with and without endometriosis. Fertil Steril 1982;38:166.PubMedGoogle Scholar
  21. 21.
    Drake TS, O’Brien WF, Ramwell PW. Peritoneal fluid thromboxane B2 and 6-ketoprostaglandin F1 in endometriosis. Am J Obstet Gynecol 1981;140:401.PubMedGoogle Scholar
  22. 22.
    Dawood MY, Khan-Dawood FS, Wilson L. Peritoneal fluid prostaglandins and prostanoids in women with endometriosis, chronic pelvic inflammatory disease and pelvic pain. Am J Obstet Gynecol 1984;148:391.PubMedGoogle Scholar
  23. 23.
    Rock JA, Dubin NH, Ghodgaonkar RB, et al. Cul-de-sac fluid in women with endometriosis: fluid volume and prostanoid concentration during the proliferative phase of the cycle days 8 to 12. Fertil Steril 1982;37:747.PubMedGoogle Scholar
  24. 24.
    Halme J, Becker S, Hammond MG, et al. Increased activation of pelvic macrophages in infertile women with mild endometriosis. Am J Obstet Gynecol 1983;145:333.PubMedGoogle Scholar
  25. 25.
    Haney AF, Muscato JJ, Weinberg JB. Peritoneal fluid cell populations in infertility patients. Fertil Steril 1981; 35:696.PubMedGoogle Scholar
  26. 26.
    Croxatto HB, Ortiz ME, Guiloff E, et al. Effect of 15 (s)-15-methyl-prostaglandin F2 on human oviductal motility and ovum transport. Fertil Steril 1978;30:408.PubMedGoogle Scholar
  27. 27.
    Pittaway DE, Maxson W, Daniell J, et al. Luteal phase defects in infertility patients with endometriosis. Fertil Steril 1983;39:712.PubMedGoogle Scholar
  28. 28.
    Winkel CA, Opsahl MS, Cowan BD. Clomiphene citrate treatment failures in women with endometriosis and luteal dysfunction. Fertil Steril 1984;41:645.Google Scholar
  29. 29.
    Schenken RS, Asch RH, Williams RF, et al. Etiology of infertility in monkeys with endometriosis: luteinized unruptured follicles, luteal phase defects, pelvic adhesions and spontaneous abortions. Fertil Steril 1984; 41:122.PubMedGoogle Scholar
  30. 30.
    Cheesman KL, Cheesman SD, Chatterton RT, et al. Alterations in progesterone metabolism and luteal function in infertile women with endometriosis. Fertil Steril 1983;43:590.Google Scholar
  31. 31.
    Cheesman KL, Ben-Nun I, Chatterton RT, et al. Relationship of luteinizing hormone, pregnanediol-3-glucouronide and estriol-16-glucouronide in urine of infertile women with endometriosis. Fertil Steril 1982; 38:542.PubMedGoogle Scholar
  32. 32.
    Metzger DA, Olive DL, Stohs GF, et al. Association of endometriosis and spontaneous abortion: effect of control group selection. Fertil Steril 1986;45:18.PubMedGoogle Scholar
  33. 33.
    Fitz Simmons J, Stahl R, Gocial B, et al. Spontaneous abortion and endometriosis. Fertil Steril 1987;47:696.Google Scholar
  34. 34.
    Donnez J, Langerock S, Thomas K. Peritoneal fluid volume, 17 beta-estradiol and progesterone concentrations in women with endometriosis and/or luteinized unruptured follicle syndrome. Gynecol Obstet Invest 1983;16:210.PubMedGoogle Scholar
  35. 35.
    Marik J, Hulka J. Luteinized unruptured follicle syndrome: a subtle case of infertility. Fertil Steril 1978; 29:270.PubMedGoogle Scholar
  36. 36.
    Dmowski WP, Rao R, Scommegna A. The luteinized unruptured follicle syndrome and endometriosis. Fertil Steril 1980;33:30.PubMedGoogle Scholar
  37. 37.
    Daly DC, Soto-Albors C, Walters C, et al. Ultrasonographic assessment of luteinized unruptured folilcle syndrome in unexplained infertility. Fertil Steril 1985; 43:62.PubMedGoogle Scholar
  38. 38.
    Brosens IA, Koninckx PR, Corveleyn PA. A study of plasma progesterone, oestradiol-17B, prolactin, and LH levels and of the luteal-phase appearance of the ovaries in patients with endometriosis and infertility. Br J Obstet Gynaecol 1978;85:246.PubMedGoogle Scholar
  39. 39.
    Koninckx PR, Ide P, Vandebrouke W, et al. New aspects of the pathophysiology of endometriosis and associated infertility. J Reprod Med 1980;24:257.PubMedGoogle Scholar
  40. 40.
    Vanrell JA, Belasch J, Fuster JS, et al. Ovulation stigma in fertile women. Fertil Steril 1982;37:712.PubMedGoogle Scholar
  41. 41.
    Kerin JF, Kirby C, Morris D, et al. Incidence of the luteinized unruptured follicle syndrome in cycling women. Fertil Steril 1983;40:620–626.PubMedGoogle Scholar
  42. 42.
    Weed JC, Arquembourg PC. Endometriosis: can it produce an autoimmune response resulting in infertility? Clin Obstet Gynecol 1988;23:885.Google Scholar
  43. 43.
    Mathur S, Peress MR, Williamson HO, et al. Autoimmunity in endometrium and ovary in endometriosis. Clin Exp Immunol 1982;50:259.PubMedGoogle Scholar
  44. 44.
    Kreiner D, Frommowitz FB, Richardson DA. Endometrial immunofluorescence associated with endometriosis and pelvic inflammatory disease. Fertil Steril 1986; 46:243.PubMedGoogle Scholar
  45. 45.
    Wild RA, Shivers CA. Antiendometrial antibodies in patients with endometriosis. Am J Reprod Immunol Microbiol 1985;8:84.PubMedGoogle Scholar
  46. 46.
    Halme J, Mathur S. Local autoimmunity in mild endometriosis. Int J Fertil 1987;32:309.PubMedGoogle Scholar
  47. 47.
    Saifuddin A, Buckley CH, Fox H. Immunoglobulin content of the endometrium in women with endometriosis. Int J Gynecol Path 1983;2:255.Google Scholar
  48. 48.
    Grimes DA, LeBolt SA, Grimes KR, et al. Systemic lupus erythematosus and reproductive function: A case-control study. Am J Obstet Gynecol 1985;153:179.PubMedGoogle Scholar
  49. 49.
    Gleicher N, El-Roliy A, Confino E, et al. Is endometriosis an autoimmune disease? Obstet Gyencol 1987; 70:115.Google Scholar
  50. 50.
    Drake T, O’Brien W, Grunert G, et al. Peritoneal fluid volume in endometriosis. Fertil Steril 190;34:280.Google Scholar
  51. 51.
    Fakih H., Baggett B, Holtz G, et al. Interleukin-1: a possible role in the fertility associated with endometriosis. Fertil Steril 1987;47:213.PubMedGoogle Scholar
  52. 52.
    VanFurth R, Raeburn JA, van Zwet TI. Characteristics of human mononuclear phagocytes. Blood 1979;54:485.Google Scholar
  53. 53.
    Austin CR. Fate of spermatozoa in the female genital tract. J Reprod Fertil 1960;1:151.Google Scholar
  54. 54.
    Hoxsey RJ, Rao R, Scommegna A. Sperm recovery in peritoneal fluid of endometriosis versus “normal” infertile patients. Fertil Steril 1984;41:395.Google Scholar
  55. 55.
    Muscato JJ, Haney AF, Weinberg JB. Sperm phagocytosis by human peritoneal macrophages: a possible cause of infertility in endometriosis. Am J Obstet Gynecol 1982;144:503.PubMedGoogle Scholar
  56. 56.
    Chacho KJ, Chacho MS, Anderson PJ, et al. Peritoneal fluid in patients with and without endometriosis: prostanoids and macrophages and their effect on the spermatozoa penetration assay. Am J Obstet Gynecol 1986; 154:1290.PubMedGoogle Scholar
  57. 57.
    Steinleitner A, Lambert H, Suarez M, et al. Immunomodulation in the treatment of endometriosis-associated subfertility: use of pentoxifylline to reverse the inhibition of fertilization by surgically induced endometriosis in a rodent model. Fertil Steril 1991a;56:975.PubMedGoogle Scholar
  58. 58.
    Steinleitner A, Lambert H, Roy S. Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: a paradigm novel approach to the treatment of endometriosis-associated subfertility. Fertil Steril 1991b;55:26.PubMedGoogle Scholar
  59. 59.
    Fayez JA, Collazo LM, Vernon C, et al. Comparison of different modalities of treatment for minimal and mild endometriosis. Am J Obstet Gynecol 1988;159:927.PubMedGoogle Scholar
  60. 60.
    Nowroozi K, Chase JS, Check JH, et al. The importance of laparoscopic coagulation of mild endometriosis in infertile women. Int J Fertil 1987;32:442.PubMedGoogle Scholar
  61. 61.
    Adamson GD, Lu J, Subak LL. Laparoscopic CO2 laser vaporization of endometriosis compared with traditional treatments. Fertil Steril 1988;50:704.PubMedGoogle Scholar
  62. 62.
    Olive DL, Lee KL. Analysis of sequential treatment protocols for endometriosis-associated infertility. Am J Obstet Gynecol 1986;154:613.PubMedGoogle Scholar
  63. 63.
    Diamond MP and the Adhesion Study Group. Postoperative adhesion development after operative lap-aroscopy: evaluation at early second-look procedures. Fertil Steril 1991;55:700.Google Scholar
  64. 64.
    Diamond MP, Daniell JF, Feste J, et al. Adhesion reformation and de novo adhesion formation after reproductive surgery. Fertil Steril 1987;47:864.PubMedGoogle Scholar
  65. 65.
    Nezhat C, Nezhat F, Metzger DA, et al. Adhesion reformation following reproductive surgery by video-laseroscopy. Fertil Steril 1990;53:1008.PubMedGoogle Scholar
  66. 66.
    Luciano AA, Turksoy RN, Carleo J. Evaluation of oral medroxyprogesterone acetate in the treatment of endometriosis. Obstet Gynecol 1988;72:323.PubMedGoogle Scholar
  67. 67.
    Evers JLH, Dunselman GAJ, Land JA, et al. Endometriosis: The management of recurrent disease. In Shaw RW, ed. Endometriosis. Carnforth, Parthenon 1990, pp 93–105.Google Scholar
  68. 68.
    Silverberg KM. Combination therapy for endometriosis. Infertil Reprod Med Clin NA 1992;3:683.Google Scholar
  69. 69.
    Buttram VC, Reiter RC, Ward S. Treatment of endometriosis with danazol: Report of a 6 year prospective study. Fertil Steril 1985;43:353.PubMedGoogle Scholar
  70. 70.
    Donnez J, Nisolle M, Clerckx F, et al. Evaluation of peroperative use of danazol, gestrinone, lynestrenol, buserelin spray and buserelin implant in the treatment of endometriosis-associated infertility. Prog Clin Biol Res 1990;323:427.PubMedGoogle Scholar
  71. 71.
    Telimmaa S, Puolakka J, Ronnberg L, et al. Placebo-controlled comparison of danazol and high-dose medroxy- progesterone acetate in the treatment of endometriosis. Gynecol Endocrinol 1987;1:13.Google Scholar
  72. 72.
    Chong AP, Koene ME, Thornton NL. Comparison of three modes of treatment for infertility patients with minimal pelvic endometriosis. Fertil Steril 1990;53:40.Google Scholar
  73. 73.
    Wheeler JM, Malinak LR. Recurrent endometriosis: Incidence, management and prognosis. Am J Obstet Gynecol 1983;146:247.PubMedGoogle Scholar
  74. 74.
    Schenken RS, Malinak LR. Reoperation after initial treatment of endometriosis with conservative surgery. Am J Obstet Gynecol 1978;131:416.PubMedGoogle Scholar
  75. 75.
    Candiani GB, Fedele L, Vercellini P, et al. Repetitive conservative surgery for recurrence of endometriosis. Obstet Gynecol 1991;77:421.PubMedGoogle Scholar
  76. 76.
    Syrop CH, Halme J. Peritoneal fluid environment and infertility. Fertil Steril 1987;48:1.PubMedGoogle Scholar
  77. 77.
    Deaton JL, Gibson M, Blackmer KM, et al. A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. Fertil Steril 1990; 54:1083.PubMedGoogle Scholar
  78. 78.
    Metzger DA, Robbins B, Tortora A, et al. Clomiphene citrate (CC) and intrauterine insemination (IUI) for the treatment of infertility. Society for Gynecologic Investigation, April 1–3, 1993, Toronto, Canada, Abstract #347.Google Scholar
  79. 79.
    Nulsen JC, Dumez S, Metzger DA. A randomized prospective trial of human menopausal gonadotropin (hMG) with intrauterine insemination (IUI) versus IUI alone in the treatment of endometriosis, male factor infertility and unexplained infertility. Obstet Gynecol (in press).Google Scholar
  80. 80.
    Metzger DA, Scott L, Nulsen JC, et al. Optimal use of human menopausal gonadotropin (hMG) superovulation combined with intrauterine insemination (IUI) as an adjunct to conservative laparoscopic surgery for the treatment of infertility associated with endometriosis. The American Association of Gynecologic Laparoscop-ists, 20th Annual Meeting, Las Vegas, NV, Nov. 13–17, 1991.Google Scholar
  81. 81.
    Jacobs SL, Metzger DA, Dodson WC, Haney AF. Effect of age on response to human menopausal gonadotropin stimulation. J Clin Endo Metab 1990;71:1525.Google Scholar
  82. 82.
    IVF Registry, 1991. Fertil Steril 1993;59:956.Google Scholar
  83. 83.
    Hulme VA, van der Merwe JP, Kruger TF. Gamete intrafallopian transfer as treatment for infertility associated with endometriosis. Fertil Steril 1990;53(6): 1095–1096.PubMedGoogle Scholar
  84. 84.
    Corson SL, Batzer FR, Gocial B, et al. Surgical treatment of endometriosis at the time of gamete intrafallopian transfer. J Repro Med 1991; 36(4):274–278.Google Scholar
  85. 85.
    Batzofin J, Tran C, Tan T, et al. Laser laparoscopy as an adjunct to assisted reproductive treatments in women with pelvic adhesions and endometriosis. J Gynecol Surg 1989;5:273.Google Scholar
  86. 86.
    Remorgida V, Anserini P, Croce S, et al. Comparison of different ovarian stimulation protocols for gamete intrafallopian transfer in patients with minimal and mild endometriosis. Fertil Steril 1990;53:1060.PubMedGoogle Scholar
  87. 87.
    Maison PL, Yovick JL. The treatment of infertility associated with endometriosis by in vitro fertilization. Fertil Steril 1986;46:432.Google Scholar
  88. 88.
    Yovick JL, Maison PL, Richardson PA, Hilliard C. Hormonal profiles and embryo quality in women with severe endometriosis treated by in vitro fertilization and embryo transfer. Fertil Steril 1988;50:308.Google Scholar
  89. 89.
    Chillik CF, Acosta AA, Garcia JE, et al. The role of in vitro fertilization in infertile patients with endometriosis. Fertil Steril 1985;44:56.PubMedGoogle Scholar
  90. 90.
    Oehninger S, Rosenwaks A. In vitro fertilization and embryo transfer: an established and successful therapy for endometriosis. Prog Clin Biol Res 1990;323:319.PubMedGoogle Scholar
  91. 91.
    Damewood MD, Rock JA. Treatment independent pregnancy with operative laparoscopy for endometriosis in an in vitro fertilization program. Fertil Steril 1988; 50:463.PubMedGoogle Scholar
  92. 92.
    Manzi DM, Metzger DA, Luciano AA, et al. The efficacy of IVF as a treatment modality for individuals with endometriosis previously failing hMG/IUI super-ovulation therapy (in preparation).Google Scholar
  93. 93.
    Classification of endometriosis. American Fertility Society. Fertil Steril 1979;32:633.Google Scholar
  94. 94.
    Garcia CR, David SS. Pelvic endometriosis: infertility and pelvic pain. Am J Obstet Gynecol 1977;129:740.PubMedGoogle Scholar
  95. 95.
    Sadigh H, Naples JD, Batt RE. Conservative surgery for endometriosis in the infertile couple. Obstet Gynecol 1977;49:562.PubMedGoogle Scholar
  96. 96.
    Buttram VC. Conservative surgery for endometriosis in the infertile female: a study of 206 patients with implications for both medical and surgical therapy. Fertil Steril 1979;31:117.PubMedGoogle Scholar
  97. 97.
    Rock JA, Guzick DS, Sengoes C, et al. The conservative surgical treatment of endometriosis: evaluation of pregnancy success with respect to the extent of disease as categorized using contemporary classification systems. Fertil Steril 1981;35:131.PubMedGoogle Scholar
  98. 98.
    Schenken RS, Malinak LR. Conservative surgery versus expectant management for the infertile patient with mild endometriosis. Fertil Steril 1982;37:183.PubMedGoogle Scholar
  99. 99.
    Rantala ML, Kahanpaa KV, Koskimies A, et al. Fertility prognosis after surgical treatment of pelvic endometriosis. Acta Obstet Gynecol Scand 1983;61:11.Google Scholar
  100. 100.
    Gordts S, Boeckx W, Brosens I. Microsurgery of endometriosis in infertile patients. Fertil Steril 1984,42:520.PubMedGoogle Scholar
  101. 101.
    Kelly RW, Roberts DK. CO2 laparoscopy. A potential alternative to danazol in the treatment of stage I and II endometriosis. J Reprod Med 1983;28:638.PubMedGoogle Scholar
  102. 102.
    Feste JR. Laser laparoscopy: a new modality. J Reprod Med 1985;30:413.PubMedGoogle Scholar
  103. 103.
    Martin DC. CO2 laser laparoscopy for endometriosis associated with infertility. J Reprod Med 1986;31:1089.PubMedGoogle Scholar
  104. 104.
    Davis GD. Management of endometriosis and its associated adhesions with the CO2 laser laparoscope. Obstet Gynecol 1986;68:422.PubMedGoogle Scholar
  105. 105.
    Donnez J. CO2 laser laparoscopy in infertile women with endometriosis and women with adnexal adhesions. Fertil Steril 1987;48:390.PubMedGoogle Scholar
  106. 106.
    Sutton C, Hill D. Laser laparoscopy in the treatment of endometriosis. A 5-year study. Br J Obstet Gynaecol 1990;97:181.PubMedGoogle Scholar
  107. 107.
    Nezhat C, Crowgey S, Nezhat F. Videolaseroscopy for the treatment of endometriosis associated with infertility. Fertil Steril 1989;51:237.PubMedGoogle Scholar
  108. 108.
    Paulson JD, Asmar P, Saffan DS. Mild and moderate endometriosis. Comparison of treatment modalities for infertile couples. J Reprod Med 1991;36:151.PubMedGoogle Scholar
  109. 109.
    Eward RD. Cauterization of stages I and II endometriosis and the resulting pregnancy rate. In Philips JM, ed. Endoscopy in Gynecology: the Proceedings of the Third International Congress on Gynecologic Endoscopy. Downey, CA, American Association of Gynecologic Laparoscopists, 1978, p 276.Google Scholar
  110. 110.
    Sulewski JM, Curcio FD, Bronitsky C, et al. The treatment of endometriosis at laparoscopy for infertility. Am J Obstet Gynecol 1980;138:128.PubMedGoogle Scholar
  111. 111.
    Seiler JC, Gidwani G, Ballard L. Laparoscopic cauterization of endometriosis for fertility: a controlled study. Fertil Steril 1986;46:1098.PubMedGoogle Scholar
  112. 112.
    Daniell JF, Christianson C. Combined laparoscopic surgery and danazol therapy for pelvic endometriosis. Fertil Steril 1981;35:521.PubMedGoogle Scholar
  113. 113.
    Barbieri RL, Evans S, Kistner RW. Danazol in the treatment of endometriosis: Analysis of 100 cases with a 4-year follow-up. Fertil Steril 1982;37:737.PubMedGoogle Scholar
  114. 114.
    Donnez J, Lemaire-Rubbers M, Karaman Y, et al. Combination (hormonal and microsurgical) therapy in infertile women with endometriosis. Fertil Steril 1987; 48:239.PubMedGoogle Scholar
  115. 115.
    Andrews WC, Larsen DC. Endometriosis: Treatment with hormonal psuedopregnancy and/or operation. Am J Obstet Gynecol 1974;118:643.PubMedGoogle Scholar
  116. 116.
    Hammond CB, Rock JA, Parker RT. Conservative treatment of endometriosis: The effects of limited surgery and hormonal pseudopregnancy. Fertil Steril 1976; 27:756.PubMedGoogle Scholar
  117. 117.
    Hammond MG, Hammond CB, Parker RT. Conservative treatment of endometriosis extera: The effects of methyltestosterone therapy. Fertil Steril 1978;29:651.PubMedGoogle Scholar
  118. 118.
    Audebert AJM, Larrue-Charlus S, Emperaire JC. Endometriosis and infertility. A reveiw of sixty-two patients treated with danazol. Postgrad Med J 1979; 55(Suppl. 5):10.PubMedGoogle Scholar
  119. 119.
    Wheeler JM, Malinak LR. Postoperative danazol therapy in infertility patients with severe endometriosis. Fertil Steril 1981;36:460.PubMedGoogle Scholar
  120. 120.
    Chong AP, Baggish MS. Management of pelvic endometriosis by means of intraabdominal carbon dioxide laser. Fertil Steril 1984;41:14.PubMedGoogle Scholar
  121. 121.
    Chong AP. Danazol versus carbon dioxide laser plus postoperative danazol: Treatment of infertility due to mild pelvic endometriosis. Lasers Surg Med 1985;5: 571.PubMedGoogle Scholar
  122. 122.
    Ronnberg L, Javiner PA. Pregnancy rates following various therapy modes for endometriosis in infertile patients. Acta Obstet Gynecol Scan Suppl 1984;123: 69.Google Scholar
  123. 123.
    Mettler L, Semm K. Three-step therapy of genital endometriosis in cases of human infertility with lynestrenol, danazol, or gestrinone administration in the second step. In Raynaud JP, ed. Medical Management of Endometriosis. New York, Raven Press, 1984, pp 233–248.Google Scholar

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© Springer-Verlag New York, Inc. 1995

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  • Deborah Metzger

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