Skip to main content
SpringerLink
Log in

Topical Tretinoin Can Correct the Structural Abnormalities of Human Photoaged Skin

  • Chapter
Evaluation and Treatment of the Aging Face

  • 157 Accesses

Abstract

Retinoids have revolutionized medical practice, especially in dermatologic disorders. A multitude of publications have demonstrated that retinoids have an extraordinary diversity of biologic effects. These include regulation of epidermal differentiation,1 increased synthesis of collagen,2 inhibition of tumor promotion,3 therapeutic antitumor effects on a variety of epithelial neoplasms,4–7 membrane integrity,7 and enhanced healing of cutaneous wounds.8

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Elias PM, Williams ML. Retinoid effects on epidermal differentiation. In: Retinoids. New Trends in Research and Therapy, JH Saurat, ed. S Karger, Basel, 1985, p. 138.

    Google Scholar 

  2. Kligman LH. Effects of all-trans retinoic acid on the dermis of hairless mice. J Am Acad Dermatol. 1986; 15:779.

    Article  CAS  PubMed  Google Scholar 

  3. Sporn MG, Newton DL. Chemoprevention of cancer with retinoids. Fed Proc 1979; 38:528.

    Google Scholar 

  4. Bollag W, Ott F. Retinoic acid topical treatment of actinic keratoses and basal cell cancers. Agents Actions. 1970; 1:172.

    Article  CAS  PubMed  Google Scholar 

  5. Meyskins FL. Studies of retinoids in the prevention and treatment of cancer. J Am Acad Dermatol. 1982; 6:824. 1982.

    Article  Google Scholar 

  6. Levine N, Meyskins FL. Topical vitamin A therapy for cutaneous malignant melanoma. Lancet. 1980; 2:224.

    Article  CAS  PubMed  Google Scholar 

  7. Elias P, Fritsch PO, Lampe M. Retinoid effects on epidermal structure, differentiation and permeability. Lab Invest. 44:531. 1988

    Google Scholar 

  8. Lee KH, Tong TG. Mechanism of action of retinyl compounds on wound healing. J Pharm Sci. 1970; 59:1195.

    Article  CAS  PubMed  Google Scholar 

  9. Tsambaos O, Orfanos CE. Ultrastructural evidence suggesting an immunomodularity activity of oral retinoid. Br J Dermatol. 1981; 104:33.

    Article  Google Scholar 

  10. Bradshaw, Cashen CH, Kennedy AJ. Antiinflammatory effects of retinoids. In: Retinoid Therapy, WJ Cunliffe, ed. MTP Press, Lancaster, p. 335. 1991

    Google Scholar 

  11. Kligman AM, Fulton JE, Plewig G. Topical vitamin A acid in acne vulgaris. Arch Dermatol. 1969; 99:469.

    Article  CAS  PubMed  Google Scholar 

  12. Kligman AM, Grove GL, Hirose R, Leyden JL. Topical tretinoin for photoaged skin. J Am Acad Dermatol. 1986; 15:836.

    Article  CAS  PubMed  Google Scholar 

  13. Gilchrest BA. Skin and Aging Processes. CRC Press, Boca Raton, 1984.

    Google Scholar 

  14. Kligman LH, Kligman AM. The nature of photoaging, its prevention and repair. Photodermatology. 1986; 3:215.

    CAS  PubMed  Google Scholar 

  15. Kligman AM. Early destruction effects of sunlight in human skin. JAMA. 1969; 210:2377.

    Article  CAS  PubMed  Google Scholar 

  16. Braverman IM, Fonferko E. Studies in cutaneous aging: the classic fiber network. J Invest Dermatol. 1982; 78:434.

    Article  CAS  PubMed  Google Scholar 

  17. Lavker RM, Kligman AM. Chronic heliodermatitis. J Invest Dermatol. 1988; 90:325.

    Article  CAS  PubMed  Google Scholar 

  18. Lavker RM. Structural alterations in exposed and unexposed aged skin. J Invest Dermatol. 1979; 73:59.

    Article  CAS  PubMed  Google Scholar 

  19. Kligman AM. Guidelines for the use of topical tretinoin for photoaged skin. J Am Acad Dermatol. 1989; 21:650.

    Article  CAS  PubMed  Google Scholar 

  20. Weiss JS, Ellis CN, Headington JT, Hamilton TA. Treatment of photodamaged facial skin with tretinoin. JAMA. 1988; 259:527.

    Article  CAS  PubMed  Google Scholar 

  21. Weinstein GD, Nigra TP, Pochi PE. Topical tretinoin for treatment of photodamaged skin. Arch Dermatol. 1991; 127:659.

    Article  CAS  PubMed  Google Scholar 

  22. Olson EA, Katz HI, Levine N, Shupak J, Bellys MM. Tretinoin emollient cream: a new therapy for photodamaged skin. J Am Acad Dermatol. 1992; 26:215.

    Article  Google Scholar 

  23. Ellis CN, Weiss JS, Voorhees JJ. Tretinoin: its use in repair of photodamage. J Cutan Aging Cosmet Dermatol. 1988; 1:33.

    Google Scholar 

  24. Leyden JJ, Grove GL, Thorne EG, Lufano L. Treatment of photodamaged facial with topical tretinoin. J Am Acad Dermatol. 1989; 21:635.

    Article  Google Scholar 

  25. Grove GL, Zerwick CR, Leyden JJ. Determination of topical tretinoin effect on cutaneous microcirculation. J Cutan Aging Cosmet Dermatol. 1988; 1:27.

    Google Scholar 

  26. Zelickson AS, Mottae JH, Weiss JS. Topical tretinoin in photoaging: an ultrastructural study. J Cutan Aging Cosmet Dermatol. 1988; 1:41.

    Google Scholar 

  27. Lever L, Kumar P, Marks R. Topical retinoic acid in the treatment of elastotic degeneration. Br J Dermatol. 1990; 122:91.

    Article  CAS  PubMed  Google Scholar 

  28. Caputo R, Monti M, Motta S, Barbaresch M. The treatment of visible signs of senescence. Br J Dermatol. 1990; 122:97.

    Article  PubMed  Google Scholar 

  29. Voorhees JJ. Clinical effects of long-term therapy with topical tretinoin. J Inter Med Res. 1990; 18:26.

    Google Scholar 

Download references

Authors
  1. Albert M. Kligman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Dermatology Center, Inc., 4535 Harding Road, 37205-2120, Nashville, TN, USA

    Melvin L. Elson M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Kligman, A.M. (1995). Topical Tretinoin Can Correct the Structural Abnormalities of Human Photoaged Skin. In: Elson, M.L. (eds) Evaluation and Treatment of the Aging Face. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8401-4_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-8401-4_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8403-8

  • Online ISBN: 978-1-4613-8401-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation