Spontaneous Growth Hormone Secretion in Children With Normal and Abnormal Growth

  • E. Verena Jorgensen
  • Dorothy I. Shulman
  • Frank B. DiamondJr.
  • Allen W. Root
  • Barry B. Bercu
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)


We have previously described the use of spontaneous growth hormone (GH) release studies in evaluating poor growth in children (1, 2). A group of children was defined as having GH neurosecretory dysfunction if they had short stature, slow growth, delayed bone age, normal responses to provocative GH testing, low insulin-like growth factor I (IGF-I) levels, and abnormal 24-h GH secretory patterns (3). These children were found to respond well to GH replacement therapy, and therefore spontaneous GH studies have been used diagnostically in many centers.


Growth Hormone Growth Velocity Precocious Puberty Height Standard Deviation Score Peak Growth Hormone 
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Copyright information

© Springer-Verlag New York, Inc. 1994

Authors and Affiliations

  • E. Verena Jorgensen
  • Dorothy I. Shulman
  • Frank B. DiamondJr.
  • Allen W. Root
  • Barry B. Bercu

There are no affiliations available

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