Abstract
We have previously described the use of spontaneous growth hormone (GH) release studies in evaluating poor growth in children (1, 2). A group of children was defined as having GH neurosecretory dysfunction if they had short stature, slow growth, delayed bone age, normal responses to provocative GH testing, low insulin-like growth factor I (IGF-I) levels, and abnormal 24-h GH secretory patterns (3). These children were found to respond well to GH replacement therapy, and therefore spontaneous GH studies have been used diagnostically in many centers.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bercu BB, Shulman D, Root AW, Spiliotis BE. Growth hormone (GH) provocative testing frequently does not reflect endogenous GH secretion. J Clin Endocrinol Metab 1986;63:709–15.
Shulman DI, Bercu BB. Evaluation of growth hormone secretion: provocative testing vs. endogenous 24-hour growth hormone profile. Acta Paediatr Scand [Suppl] 1987;337:61–71.
Spiliotis BE, August GP, Hung W, Sonis W, Mendelson W, Bercu BB. Growth hormone neurosecretory dysfunction: a treatable cause of short stature. JAMA 1984;251:2223–30.
Tanner JM. Growth at adolescence. Springfield, IL: Charles C. Thomas, 1972.
Hammer LD, Kraemer HC, Wilson DM, Ritter PL, Dornbusch SM. Standardized percentile curves of body-mass index for children and adolescents. Am J Dis Child 1991;145:259–63.
Greulich WW, Pyle SJ. Radiographic atlas of skeletal development of the hand and wrist. Palo Alto, CA: Stanford University Press, 1973.
Root AW, Rosenfield RL, Bongiovanni AM, Eberlein WR. The plasma growth hormone response to insulin-induced hypoglycemia in children with retardation of growth. Pediatrics 1967;39:844–52.
Reiter EO, Root AW. The effect of pyridoxine in pituitary release of growth hormone and prolactin in childhood and adolescence. J Clin Endocrinol Metab 1978;47:689–90.
Veldhuis JD, Johnson ML. Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol 1986;250:E486–93.
Reiter EO, Morris AH, MacGillivray MH, Weber D. Variable estimates of serum growth hormone concentrations by different radioassay systems. J Clin Endocrinol Metab 1988;66:68–71.
Hindmarsh P, Smith PJ, Brook CGD, Matthews DR. The relationship between height velocity and growth hormone secretion in short prepubertal children. Clin Endocrinol 1987;27:581–91.
Spadoni GL, Cianfarani S, Bernardini S, et al. Twelve-hour spontaneous nocturnal growth hormone secretion in growth retarded patients. Clin Pediatr 1988;27:473–8.
Rochiccioli P, Messina A, Tauber MT, Enjaume C. Correlation of the parameters of 24-hour growth hormone secretion with growth velocity in 93 children of varying height. Horm Res 1989;31:115–8.
Zadik Z, Chalew SA, Kowarski A. Assessment of growth hormone secretion in normal stature children using 24-hour integrated concentration of GH and pharmacological stimulation. J Clin Endocrinol Metab 1990;71:932–6.
Lin T-H, Kirkland RT, Sherman BM, Kirkland JL. Growth hormone testing in short children and their response to growth hormone therapy. J Pediatr 1989;115:57–63.
Albertsson-Wikland K, Rosberg S. Analyses of 24-hour growth hormone profiles in children: relation to growth. J Clin Endocrinol Metab 1988; 67:493–500.
Costin G, Kaufman FR, Brasel JA. Growth hormone secretory dynamics in subjects with normal stature. J Pediatr 1989;115:537–44.
Martha PM Jr, Rogol AD, Veldhuis JD, Kerrigan JR, Goodman DW, Blizzard RM. Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys. J Clin Endocrinol Metab 1989;69:563–70.
Rose SR, Municchi G, Barnes KM, et al. Spontaneous growth hormone secretion increases during puberty in normal girls and boys. J Clin Endocrinol Metab 1991;73:428–35.
Veldhuis JD, Iranmanesh A, Ho KKY, Waters MJ, Johnson ML, Lizarralde G. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 1991;72:51–9.
Blatt J, Bercu BB, Gillin JC, Mendelson WB, Poplack DG. Reduced pulsatile growth hormone secretion in children after therapy of acute lymphoblastic leukemia. J Pediatr 1984;104:182–6.
Romshe CA, Zipf WB, Miser A, Miser J, Sotos JF, Newton WA. Evaluation of growth hormone release and human growth hormone treatment in children with irradiation-associated short stature. J Pediatr 1984;104:177–81.
Costin G. Effects of low-dose cranial radiation on growth hormone secretory dynamics and hypothalamic-pituitary function. Am J Dis Child 1988;142: 847–52.
Ross JL, Long LM, Loriaux DL, Cutler GB. Growth hormone secretory dynamics in Turner syndrome. J Pediatr 1985;106:202–6.
Lin T-H, Kirkland JL, Kirkland RT. Growth hormone assessment and short-term treatment with growth hormone in Turner syndrome. J Pediatr 1988;112:919–22.
Zadik Z, Landau H, Chen M, Altman Y, Lieberman E. Assessment of growth hormone (GH) axis in Turner’s syndrome using 24-hour integrated concentrations of GH, insulin-like growth factor-1, plasma GH-binding activity, GH binding to IM9 cells, and GH response to pharmacological stimulation. J Clin Endocrinol Metab 1992;75:412–6.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag New York, Inc.
About this paper
Cite this paper
Jorgensen, E.V., Shulman, D.I., Diamond, F.B., Root, A.W., Bercu, B.B. (1994). Spontaneous Growth Hormone Secretion in Children With Normal and Abnormal Growth. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_22
Download citation
DOI: https://doi.org/10.1007/978-1-4613-8372-7_22
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-8374-1
Online ISBN: 978-1-4613-8372-7
eBook Packages: Springer Book Archive