Ionic Mechanisms Governing the Control of Growth Hormone Secretion by Somatostatin

  • Jacob Kraicer
  • Stephen M. Sims
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)


Readers are referred to a recent symposium (1) and reviews (2–4) for a comprehensive and broad introduction to somatostatin (SS) and its actions. This chapter will be restricted to the mechanisms (primarily ionic) by which SS inhibits growth hormone (GH) release. The abundant literature on the actions of SS on other cell types will not be discussed unless directly relevant to ionic mechanisms in somatotrophs. We will begin by summarizing the ionic mechanisms by which growth hormone releasing factor (GRF) stimulates the acute release of GH via cyclic AMP (cAMP) and cytosolic free Ca++ ([Ca++]i) as second messengers (Fig. 2.1). This is discussed in more detail elsewhere in this volume.


Growth Hormone Pituitary Cell Growth Hormone Secretion Growth Hormone Release Growth Hormone Release Factor 
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Copyright information

© Springer-Verlag New York, Inc. 1994

Authors and Affiliations

  • Jacob Kraicer
  • Stephen M. Sims

There are no affiliations available

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