Luteotropic and Luteolytic Effects of Peptides in the Porcine and Human Corpus Luteum

  • Wolfgang Wuttke
  • Hubertus Jarry
  • Lutz Pitzel
  • Eva Dietrich
  • Sabine Spiess
Part of the Proceedings in the Serono Symposia, USA Series book series (SERONOSYMP)


The ovaries of most species studied so far contain numerous regulatory peptides, growth factors, and cytokines (reviewed in 1, 2). Many of these peptides are produced by steroidogenic cells (i.e., granulosa, theca, or luteal cells). In addition, the sympathetic and parasympathetic nerve fibers innervating the ovaries also contain numerous neuropeptides (3, 4), many of which are also produced locally by steroidogenic cells. Only a few of the peptides are secreted into the circulation in amounts that allow systemic effects. Most of them exert autocrine and/or paracrine effects within the ovary. Evidence has accumulated that ovulation, the process of corpus luteum (CL) formation, CL function, and spontaneous regression (luteolysis) of the CL are regulated by such autocrine- and paracrine-acting factors (1, 5).


Tumor Necrosis Factor Vasoactive Intestinal Peptide Luteal Phase Corpus Luteum Luteal Cell 
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  1. 1.
    Auletta FJ, Flint APF. Mechanisms controlling corpus luteum function in sheep, cows, nonhuman primates, and woman especially in relation to the time of luteolysis. Endocr Rev 1988; 9: 88–105.PubMedCrossRefGoogle Scholar
  2. 2.
    Niswender GD, Schwa II RH, Fitz TA, Farin CE, Sawyer HR. Regulation of luteal function in domestic ruminants: new concepts. Recent Prog Horm Res 1985; 41: 101–42.PubMedGoogle Scholar
  3. 3.
    Ojeda SR, Lara H, Ahmed CE. Potential relevance of vasoactive intestinal peptide to ovarian physiology. Semin Reprod Endocrinol 1989; 7: 52–60.CrossRefGoogle Scholar
  4. 4.
    McDonald JK, Dees WL, Ahmed CE, Noe BD, Ojeda SR. Biochemical and immunocytochemical characterization of neuropeptide Y in the immature rat ovary. Endocrinology 1987; 120: 1703–10.PubMedCrossRefGoogle Scholar
  5. 5.
    Lamsa JC, Kot SJ, Elderding JA, Nay MG, McCracken JA. Prostaglandin F2α-stimulated release of ovarian oxytocin in the sheep in vivo: threshold and dose dependancy. Biol Reprod 1989; 40: 1215–23.PubMedCrossRefGoogle Scholar
  6. 6.
    Conley AJ, Ford SP. Direct luteotrophic effect of oestradiol-17β on pig corpora lutea. J Reprod Fertil 1989; 87: 125–31.PubMedCrossRefGoogle Scholar
  7. 7.
    Pitzel L, Jarry H, Wuttke W. Effects of oxytocin on in vitro steroid release of midstage small and large porcine luteal cells. Endocrinology 1990; 126: 2343–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Jarry H, Einspanier A, Kanngieber L, et al. Release and effects of oxytocin on estradiol and progesterone secretion in porcine corpora lutea as measured by an in vivo microdialysis system. Endocrinology 1990; 126: 2350–8.PubMedCrossRefGoogle Scholar
  9. 9.
    Hansel W, Dowd JP. New concept of the control of corpus luteum function. J Reprod Fertil 1986; 78: 755–68.PubMedCrossRefGoogle Scholar
  10. 10.
    Pitzel L, Jarry H, Wuttke W. Effects of substance-P and neuropeptide-Y on in vitro steroid release by porcine granulosa and luteal cells. Endocrinology 1991; 129: 1059–65.PubMedCrossRefGoogle Scholar
  11. 11.
    Maas S, Jarry H, Teichmann A, Rath W, Kuhn W, Wuttke W. Paracrine actions of oxytocin, prostaglandin F, and estradiol within the human corpus luteum. J Clin Endocrinol Metab 1992; 74; 306–12.PubMedCrossRefGoogle Scholar
  12. 12.
    Einspanier A, Jarry H, Pitzel L, Holtz W, Wuttke W. Determination of secretion rates of estradiol, progesterone, oxytocin, and angiotensin II from tertiary follicles and freshly formed corpora lutea in freely moving sows. Endocrinology 1991; 129: 3403–9.PubMedCrossRefGoogle Scholar
  13. 13.
    Jarry H, Düker EM, Wuttke W. Adrenal release of catecholamines and metenkephalin before and after stress as measured by a novel in vivo dialysis method in the rat. Neurosci Lett 1985; 60: 273–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Jarry H, Dietrich M, Düker EM, Wuttke W. Effects of systemic and local administration of etomidate on adrenocortical steroidogenesis in male rats. Acta Endocrinol (Copenh) 1987; 114: 402–9.Google Scholar
  15. 15.
    Pitzel L, Jarry H, Wuttke W. In the porcine corpus luteum the luteotrophic effects of PGF and oxytocin become luteolytic through the action of cytokines. Endocrinology (in press).Google Scholar
  16. 16.
    Pitzel L, Wuttke W. Differential steroidogenic response of porcine small and large luteal cells deriving from young or old corpora lutea. Acta Endocrinol (Copenh) 1990; 122: 119.Google Scholar
  17. 17.
    Pitzel L, Jarry H, Wuttke W. Demonstration of oxytocin receptors in porcine corpora lutea; comparison of receptor properties in young vs. old corpora lutea. Biol Reprod (in press).Google Scholar
  18. 18.
    Gross TS, Thatcher WW, Hansen PJ, Lacroix MC. Prostaglandin secretion by perifused bovine endometrium: secretion towards the myometrial and luminal sides at day 17 post-estrus as altered by pregnancy. Prostaglandins 1988; 35: 343–53.PubMedCrossRefGoogle Scholar
  19. 19.
    Murdoch WJ. Treatment of sheep with prostaglandin F enhances production of a luteal chemoattractant for eosinophils. Am J Reprod Immunol Microbiol 1987; 15: 52.PubMedGoogle Scholar
  20. 20.
    Fairchild-Benyo D, Pate JL. Tumor necrosis factor-α alters bovine luteal cell synthetic capacity and viability. Endocrinology 1992; 130: 854–60.CrossRefGoogle Scholar
  21. 21.
    Sancho-Tello M, Perez-Roger I, Imakawa K, Tilzer L, Terranova PF. Expression of tumor necrosis factor-a in the rat ovary. Endocrinology 1992; 130: 1359–64.PubMedCrossRefGoogle Scholar

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© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Wolfgang Wuttke
  • Hubertus Jarry
  • Lutz Pitzel
  • Eva Dietrich
  • Sabine Spiess

There are no affiliations available

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