Luteotropic and Luteolytic Effects of Peptides in the Porcine and Human Corpus Luteum

  • Wolfgang Wuttke
  • Hubertus Jarry
  • Lutz Pitzel
  • Eva Dietrich
  • Sabine Spiess
Part of the Proceedings in the Serono Symposia, USA Series book series (SERONOSYMP)

Abstract

The ovaries of most species studied so far contain numerous regulatory peptides, growth factors, and cytokines (reviewed in 1, 2). Many of these peptides are produced by steroidogenic cells (i.e., granulosa, theca, or luteal cells). In addition, the sympathetic and parasympathetic nerve fibers innervating the ovaries also contain numerous neuropeptides (3, 4), many of which are also produced locally by steroidogenic cells. Only a few of the peptides are secreted into the circulation in amounts that allow systemic effects. Most of them exert autocrine and/or paracrine effects within the ovary. Evidence has accumulated that ovulation, the process of corpus luteum (CL) formation, CL function, and spontaneous regression (luteolysis) of the CL are regulated by such autocrine- and paracrine-acting factors (1, 5).

Keywords

Estrogen Angiotensin Prostaglandin Luminal Tamoxifen 

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Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Wolfgang Wuttke
  • Hubertus Jarry
  • Lutz Pitzel
  • Eva Dietrich
  • Sabine Spiess

There are no affiliations available

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