Evolution of Concepts of Myocardial Function in the Treatment of Congestive Heart Failure in Man

  • Richard Gorlin
  • Jeffrey D. Hosenpud
  • Barry H. Greenberg


Over the past 50 years, our understanding of cardiac function in normal and pathophysiologic states has evolved considerably. Not surprisingly, this has resulted in a great many changes in the way that we approach the management of patients with congestive heart failure (CHF). It seems fitting, then, in this introductory chapter of a new textbook on CHF, to provide a brief overview of some of these changes and to draw the important connection between advances in basic science and those in clinical medicine.


Ejection Fraction Congestive Heart Failure Diastolic Dysfunction Filling Pressure Myocardial Function 
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  1. 1.
    Hellems HK, Haynes FW, Dexter L, Kinney TD. Pulmonary capillary pressure in animals estimated by venous and arterial catheterization. Am J Physiol. 1948;155:98–105.PubMedGoogle Scholar
  2. 2.
    Starling EH. Linacre Lecture on the Law of the Heart given at Cambridge, 1915. 27 pp. London, Longmans, 1918.Google Scholar
  3. 3.
    Wiggers CJ. Modern Aspects of the Circulation in Health and Disease. Philadelphia: Lea and Febiger; 1923.Google Scholar
  4. 4.
    Katz LN. The performance of the heart. (The Lewis A. Conner Memorial Lecture). Circulation. 1960;21:483–498.PubMedGoogle Scholar
  5. 5.
    Sarnoff SJ. Myocardial contractility as described by ventricular function curves; observations on Starling’s law of the heart. Physiol. Rev. 1955;35:107–122.PubMedGoogle Scholar
  6. 6.
    Braunwald E, Frye RL, Aygen MM, Gilbert JW. Studies on Starling’s law of the heart III. Observations in patients with mitral stenosis and atrial fibrillation on relationships between left ventricular end-diastolic segment length, filling pressure, and characteristics of ventricular contraction. J Clin Invest. 1960;39:1874–1884.PubMedCrossRefGoogle Scholar
  7. 7.
    Harrison TR. Failure of the Circulation. Baltimore: Williams & Wilkins; 1935.Google Scholar
  8. 8.
    Warren JV, Stead EA Jr. Fluid dynamics in chronic congestive heart failure. An interpretation of the mechanisms producing the edema, increased plasma volume and elevated venous pressure in certain patients with prolonged congestive failure. Arch Intern Med. 1944;73:138–147.Google Scholar
  9. 9.
    Abbott BC, Mommaerts WFHM. Study of inotropic mechanisms in the papillary muscle preparation. J Gen Physiol. 1959;42:533–551.PubMedCrossRefGoogle Scholar
  10. 10.
    Sonnenblick EH. Force-velocity relations in mammalian heart muscle. Am J Physiol. 1962;202:931–939.PubMedGoogle Scholar
  11. 11.
    Dodge HT, Hay RE, Sandler H. Pressure-volume characteristics of the diastolic left ventricle of man with heart disease. Am Heart J. 1962;64:503–511.PubMedCrossRefGoogle Scholar
  12. 12.
    Gorlin R, Sonnenblick EH. Regulation of performance of the heart. Am J Cardiol. 1968;22:16–23.PubMedCrossRefGoogle Scholar
  13. 13.
    Bemis CE, Serur JR, Borkenhagen D, Sonnenblick EH, Urschel CW. Influence of right ventricular filling pressure and dimension. Circ Res. 1974;34:498–504.PubMedGoogle Scholar
  14. 14.
    Rushmer RF. Cardiovascular Dynamics. Philadelphia: Saunders; 1961.Google Scholar
  15. 15.
    Gorlin R, Rolett EL, Yurchak PM, Elliott WC. Left ventricular volume in man measured by thermodilution. J Clin Invest. 1964;43:1203–1221.PubMedCrossRefGoogle Scholar
  16. 16.
    Grossman W. Diastolic dysfunction and congestive heart failure. Circulation. 1990;81(suppl III):III–l-III-7.Google Scholar
  17. 17.
    Herman MV, Heinle RA, Klein MD, Gorlin R. Localized disorders in myocardial contraction. Asynergy and its role in congestive heart failure. N Engl J Med. 1967;277:222–232.PubMedCrossRefGoogle Scholar
  18. 18.
    Cohn PF, Gorlin R, Collins JJ, Cohn L. The left ventricular ejection fraction as a prognostic guide in the surgical treatment of coronary and valvular heart disease. Am J Cardiol. 1974;34:135–141.CrossRefGoogle Scholar
  19. 19.
    V-HeFT Study. Effect of vasodilator therapy on mortality in chronic congestive heart failure.N Engl J Med. 1986;314:1547–1552.CrossRefGoogle Scholar
  20. 20.
    The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991; 325:293–302.CrossRefGoogle Scholar
  21. 21.
    White HD, Nords RM, Brown MA, Brandt PWT, Whitlock RML, Wild CJ. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation. 1987;76:44–51.PubMedCrossRefGoogle Scholar
  22. 22.
    Hammermeister KE, Chikos PM, Fisher LL, Dodge HT. Relationship of cardiothoracic ratio and plain film heart volume to late survival. Circulation. 1979;59:89–95.PubMedGoogle Scholar
  23. 23.
    Douglas PA, Morrow R, Ioli A, Reichek N. Left ventricular shape, afterload and survival in idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 1989;13:311–315.PubMedCrossRefGoogle Scholar
  24. 24.
    The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992;327:685–691.CrossRefGoogle Scholar
  25. 25.
    The SAVE Investigators. Effect of Captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 1992;327:669–677.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1994

Authors and Affiliations

  • Richard Gorlin
  • Jeffrey D. Hosenpud
  • Barry H. Greenberg

There are no affiliations available

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