Clinical Trials of Ticlopidine in Patients with Intermittent Claudication

  • Lars Janzon


Atherosclerosis is the main pathophysiologic process behind peripheral arterial disease (PAD).1 Like other atherosclerotic manifestations, PAD is more common in old people than young and more common in men than women. The clinical spectrum of PAD ranges from an asymptomatic stage with weak leg arterial pulsations, a femoral bruit, or an abnormal systolic arm-ankle pressure gradient, to a symptomatic stage with intermittent claudication, rest pain, and gangrene. Depending on different clinical criteria and varying methods of assessing leg blood flow, the prevalence of PAD varies from one study to another. Several publications have presented prevalence estimates of intermittent claudication as being 2% in middle-aged men and 1% in middle-aged women.2–4 Study findings by Reunanen et al.2 support the clinical experience that PAD is becoming more common in women. Among 30–39-year-olds in that study, the prevalence of intermittent claudication was twice as high in women as in men.


Peripheral Arterial Disease Peripheral Artery Disease Intermittent Claudication Venous Occlusion Plethysmography Hematological Side Effect 
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© Springer-Verlag New York Inc. 1993

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  • Lars Janzon

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