Genetic Structure of the HLA Region and Implication for Function
A number of human disease processes are strongly associated with certain antigens of the HLA system. Although HLA antigens, expressed on most body tissues, are the “strong” barriers to tissue transplantation, their role outside of the medical artifacts of transplantation and transfusion has not been clearly appreciated. Review of this area requires first an outline of what is known of The genes and gene products of the HLA major histocompatibility complex (MHC), followed by a summary of some of the principal disease relationships and discussion of the potential mechanisms of such associations in relation to the immunobiological role of the MHC.
KeywordsArthritis Hepatitis Leukemia Recombination Psoriasis
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