Skip to main content
SpringerLink
Log in

Biochemical Adaptations to Endurance Exercise in Skeletal Muscle

  • Chapter
Muscle Metabolism During Exercise

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 11))

Abstract

The adaptations that occur in response to a vigorous program of prolonged exercise, such as long distance running or swimming, manifest themselves in functional terms as an increase in endurance. In the present context, an increase in endurance can be defined simply as an increase in the period of time for which an individual can maintain a given submaximal level of exercise. A logical first question in an investigation of the physiological basis for this increase in endurance is - What are the factors that force an individual to stop exercising, and how do the adaptations to physical training modify these factors?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahlborg, B., Bergström, J., Ekelund, L.-G., and Hultman, E., Acta physiol. scand., 70, 129 (1967).

    Article  CAS  Google Scholar 

  2. Hermansen, L., Hultman, E., and Saltin, B., Acta physiol. scand., 71, 129 (1967).

    Article  PubMed  CAS  Google Scholar 

  3. Bergstrom, J., Hermansen, L., Hultman, E., and Saltin, B., Acta physiol. scand., 71, 140 (1967).

    Article  PubMed  CAS  Google Scholar 

  4. Christensen, E. H., and Hansen, O., Skand. Arch. Physiol., 81, 160 (1939).

    Google Scholar 

  5. Havel, R. J., Carlson, L. A., Ekelund, L.-G., and Holmgren, A., J.Appl. Physiol., 19, 613 (1964).

    PubMed  CAS  Google Scholar 

  6. Issekutz, B., Miller, H. I., Paul, P., and Rodahl, K., J. Appl. Physiol., 20, 293 (1965).

    CAS  Google Scholar 

  7. Diamant, B., Karlsson, J., and Saltin, B., Acta physiol. scand., 72, 383 (1968).

    Article  PubMed  CAS  Google Scholar 

  8. Carlsten, A., In Physical Activity and Aging (D. Brunner and E. Joki, eds.), p. 37, University Park Press, Baltimore (1970).

    Google Scholar 

  9. Hill, A. V., and Kupalov, P., Proc. Roy. Soc. (London) Ser. B., 105, 313 (1929).

    Article  CAS  Google Scholar 

  10. Edwards, H. T., Brouha, L., and Johnson, R. E., Le Travail Humain, 8, 1 (1939).

    Google Scholar 

  11. Robinson, S., and Harmon, P. M., Am. J. Physiol., 132, 757 (1941).

    CAS  Google Scholar 

  12. Holmgren, A., and Strom, G., Acta Medica Scand., 163, 185 (1959).

    Article  CAS  Google Scholar 

  13. Cobb, L. A., and Johnson, W. P., J. Clin. Invest., 42, 800 (1963).

    Article  PubMed  CAS  Google Scholar 

  14. Varnauskas, E., Bergman, H., Houk, P., and Bjorntörp, P., Lancet, 2, 8 (1966).

    Article  PubMed  CAS  Google Scholar 

  15. Frick, M. H., and Katila, M., Circulation, 37, 192 (1968).

    Google Scholar 

  16. Clausen, J. P., Larsen, O. A., and Trap-Jensen, J., Circulation, 40, 143 (1969).

    PubMed  CAS  Google Scholar 

  17. Frick, M. H., Konttinen, A., and Sarajas, H. S. S., Am. J. Cardiol., 12, 142 (1963).

    Article  PubMed  CAS  Google Scholar 

  18. Holloszy, J. O., J. Biol. Chem., 242, 2278 (1967).

    PubMed  CAS  Google Scholar 

  19. Fuge, K. W., Crews, E. L., Pattengale, P. K., Holloszy, J. O., and Shank, R. E., Am. J. Physiol., 215, 660 (1968).

    PubMed  CAS  Google Scholar 

  20. Holloszy, J. O., Oscai, L. B., Don, I., and Molé, P. A., Biochem. Biophys. Res. Commun., In Press.

    Google Scholar 

  21. Holloszy, J. O., and Oscai, L. B., Arch. Biochem. Biophys., 130, 653 (1969).

    Article  PubMed  CAS  Google Scholar 

  22. Golinick, P. D., and King, D. W., Am. J. Physiol., 216, 1502 (1969).

    Google Scholar 

  23. Kraus, H., Kirsten, R., and Wolff, J. R., Pflugers Arch., 308, 57 (1969).

    Article  PubMed  CAS  Google Scholar 

  24. Oscai, L. B., and Holloszy, J. O., (In Preparation).

    Google Scholar 

  25. Molé, P. A., Oscai, L. B., and Holloszy, J. O., (In Preparation).

    Google Scholar 

  26. Penefsky, H. S., Pullman, M. E., Datta, A., and Racker, E., J. Biol. Chem., 235, 3330 (1960).

    PubMed  CAS  Google Scholar 

  27. Fessenden, J. M., and Racker, E., J. Biol. Chem., 241, 2483 (1966).

    PubMed  CAS  Google Scholar 

  28. Pullman, M. E., and Monroy, C. C., J. Biol. Chem., 238, 3762 (1963).

    PubMed  CAS  Google Scholar 

  29. Racker, E., and Horstman, L. L., J. Biol. Chem., 242, 2547 (1967).

    PubMed  CAS  Google Scholar 

  30. Havel, R. J., Naimark, A., and Borchgrevink, C. F., J. Clin. Invest., 42, 1054 (1963).

    Article  PubMed  CAS  Google Scholar 

  31. Paul, P., and Issekutz, B., J. Appl. Physiol., 22, 615 (1967).

    PubMed  CAS  Google Scholar 

  32. Zierler, K. L., Maseri, A., Klassen, G., Rabinowitz, D., and Burgess, J., Trans. Ass. Amer. Physicians, 8, 266 (1968).

    Google Scholar 

  33. Issekutz, B., Miller, H. I., and Rodahl, K., Fed. Proc., Fed. Amer. Soc. Exp. Biol., 25, 1415 (1966).

    CAS  Google Scholar 

  34. Molé, P. A., and Holloszy, J. O., Proc. Soc. Exp. Biol. Med., 134, 789 (1970).

    PubMed  Google Scholar 

  35. Pattengale, P. K., and Holloszy, J. O., Am. J. Physiol., 213 783 (1967).

    PubMed  CAS  Google Scholar 

  36. Peter, J. B., Jeffress, R. N., and Lamb, D. R., Science, 160, 200 (1968).

    Article  PubMed  CAS  Google Scholar 

  37. Lamb, D. R., Peter, J. B., Jeffress, R. N., and Wallace, H. A., Am. J. Physiol., 217, 1628 (1969).

    PubMed  CAS  Google Scholar 

  38. Williams, J. N., and Thorp, S. L., Biochem. Biophys. Acta, 189, 25 (1969).

    Article  PubMed  CAS  Google Scholar 

  39. King, T. E., Methods Enzymol., 10, 322 (1967).

    Article  CAS  Google Scholar 

  40. Srere, P. A., Methods Enzymol., 13, 3 (1969).

    Article  CAS  Google Scholar 

  41. Dart, C. H., and Holloszy, J. O., Circulation Res., 25, 245 (1969).

    PubMed  CAS  Google Scholar 

  42. Holloszy, J. O., and Narahara, H. T., J. Biol. Chem., 240, 3493 (1965).

    PubMed  CAS  Google Scholar 

  43. Lardy, H. A., and Wellman, H., J. Biol. Chem., 201, 357 (1953).

    PubMed  CAS  Google Scholar 

  44. Chance, B., and Williams, C. R., Advan. Enzymol., 17, 65 (1956).

    CAS  Google Scholar 

  45. Chance, B., Ann. N. Y. Acad. Sci., 81, 477 (1959).

    Article  PubMed  CAS  Google Scholar 

  46. Chance, B., and Maitra, P. K., In Control Mechanisms in Respiration and Fermentation (Wright, B., ed.), p. 307, Ronald Press, New York (1963).

    Google Scholar 

  47. Klingenberg, M., and Schollmeyer, P., Biochem. Z., 335, 231 (1961).

    PubMed  CAS  Google Scholar 

  48. Klingenberg, M., and von Hafen, H., Biochem. Z., 337, 120 (1963).

    PubMed  CAS  Google Scholar 

  49. Henry, F. M., and DeMoor, J., J. Appl. Physiol., 8, 608 (1956).

    PubMed  CAS  Google Scholar 

  50. Margaria, R., Mangili, F., Cuttica, F., and Cerretelli, P., Ergonomics, 8, 49 (1965).

    Article  Google Scholar 

  51. Piiper, J., Di Prampero, P. E., and Cerretelli, P., Am. J. Physiol., 215, 523 (1968).

    PubMed  CAS  Google Scholar 

  52. Wu, R., and Racker, E., J. Biol. Chem., 234, 1029 (1959).

    PubMed  CAS  Google Scholar 

  53. Chance, B., Garfinkel, D., Higgens, J., and Hess, B., J. Biol. Chem., 235, 2426 (1960).

    PubMed  CAS  Google Scholar 

  54. Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., and Schulz, D. W., J. Biol. Chem., 239, 18 (1964).

    PubMed  CAS  Google Scholar 

  55. Uyeda, K., and Racker, E., J. Biol. Chem., 240, 4689 (1965).

    PubMed  CAS  Google Scholar 

  56. Racker, E., In Mechanisms in Bioenergetics, p. 252, Academic Press, New York (1965).

    Google Scholar 

  57. Lehninger, A. L., In The Mitochondrion, p. 152, W. A. Benjamin, Inc., New York (1965).

    Google Scholar 

  58. Mahler, H. R., and Cordes, E. H., Biological Chemistry, p. 422, Harper and Row, Publishers, New York (1966).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Preventive Medicine, Washington University School of Medicine, St. Louis, Missouri, USA, 63110

    J. O. Holloszy, L. B. Oscai, P. A. Molé & I. J. Don

Authors
  1. J. O. Holloszy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. B. Oscai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. A. Molé
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. J. Don
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Clinical Physiology, Serafimerlasarettet, Karolinska Institutet, Stockholm, Sweden

    Bengt Pernow (Associate Professor and Chairman) (Associate Professor and Chairman)

  2. Department of Physiology, Gymnastik & Idrottshögskolan, Stockholm, Sweden

    Bengt Saltin (Associate Professor) (Associate Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Plenum Press, New York

About this chapter

Cite this chapter

Holloszy, J.O., Oscai, L.B., Molé, P.A., Don, I.J. (1971). Biochemical Adaptations to Endurance Exercise in Skeletal Muscle. In: Pernow, B., Saltin, B. (eds) Muscle Metabolism During Exercise. Advances in Experimental Medicine and Biology, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4609-8_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4609-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4611-1

  • Online ISBN: 978-1-4613-4609-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation