Myocardial Metabolism in Man at Rest and During Prolonged Exercise

  • B. W. Lassers
  • L. Kaijser
  • M. L. Wahlqvist
  • L. A. Carlson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 11)


The technique of coronary sinus catheterisation with measurement of arterio-venous differences across the heart has provided considerable information about the uptake and utilization of plasma substrates by the myocardium in resting man. There is general agreement that in the resting fasting state plasma free fatty acids (FFA) and glucose are the principle substrates for myocardial oxidation with smaller contributions being made by plasma lactate, pyruvate and ketone bodies (1,2,3,4,5,6). However, despite the finding of triglyceride uptake by the isolated animal heart (7,8,9,10,11,12), and the demonstration of the presence of lipoprotein lipase activity in the human heart (13,l1), coronary sinus catheterisation studies in man have failed to demonstrate satisfactorily the uptake of plasma triglycerides by individual hearts.


Free Fatty Acid Coronary Sinus Plasma Triglyceride Prolonged Exercise Myocardial Metabolism 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • B. W. Lassers
    • 1
    • 2
  • L. Kaijser
    • 1
    • 2
  • M. L. Wahlqvist
    • 1
    • 2
  • L. A. Carlson
    • 1
    • 2
  1. 1.Department of GeriatricsUniversity of UppsalaUppsala
  2. 2.Department of Clinical PhysiologyKarolinska Sjukhuset and King Gustaf V Research InstituteStockholmSweden

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