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Myocardial Metabolism in Man at Rest and During Prolonged Exercise

  • B. W. Lassers
  • L. Kaijser
  • M. L. Wahlqvist
  • L. A. Carlson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 11)

Abstract

The technique of coronary sinus catheterisation with measurement of arterio-venous differences across the heart has provided considerable information about the uptake and utilization of plasma substrates by the myocardium in resting man. There is general agreement that in the resting fasting state plasma free fatty acids (FFA) and glucose are the principle substrates for myocardial oxidation with smaller contributions being made by plasma lactate, pyruvate and ketone bodies (1,2,3,4,5,6). However, despite the finding of triglyceride uptake by the isolated animal heart (7,8,9,10,11,12), and the demonstration of the presence of lipoprotein lipase activity in the human heart (13,l1), coronary sinus catheterisation studies in man have failed to demonstrate satisfactorily the uptake of plasma triglycerides by individual hearts.

Keywords

Free Fatty Acid Coronary Sinus Plasma Triglyceride Prolonged Exercise Myocardial Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bing, R.J., Siegel, A., Vitale, A., Balboni, F., Sparks, E., Taeschler, M., Klapper, M., Edwards, S.: Metabolic studies on the human heart in vivo. I. Studies on carbohydrate metabolism of the human heart. Amer. J. Med. 15: 284, 1953.PubMedCrossRefGoogle Scholar
  2. 2.
    Bing, R.J., Siegel, A., Ungar, I., Gilbert, M.: Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism. Amer. J. Med. 16: 504, 1954.PubMedCrossRefGoogle Scholar
  3. 3.
    Goodale, W.T., Olson, R.E., Hackel, D.B.: The effects of fasting and diabetes mellitus on nrocardia1 metabolism in man. Amer. J. Med. 27: 212, 1959.PubMedCrossRefGoogle Scholar
  4. 4.
    Harris, P., Jones, J.H., Bateman, M., Chlouverakis, C., Gloster, J.: Metabolism of the myocardium at rest and during exercise in patients with rheumatic heart disease. Clin. Sci. 26: 145, 1964.PubMedGoogle Scholar
  5. 5.
    Rudolph, W., Maas, D., Richter, J., Hasinger, F., Hofmann, H., Dohrn, P.: über die Bedeutung von Acetacetat und α-Hydroxybutyrat im Stoffwechsel des menschlichen Herzens. Klin. Wchnschr. 43: 445, 1965.CrossRefGoogle Scholar
  6. 6.
    Most, A.S., Brachfeld, N., Gorlin, B., Währen, J.: Free fatty acid metabolism of the human heart at rest. J. Clin. Invest. 48: 1177, 1969.PubMedCrossRefGoogle Scholar
  7. 7.
    Gousios, A., Felts, J.M., Havel, R.J.: The metabolism of serum triglycerides and free fatty acids by the myocardium. Metabolism 12: 75, 1963.PubMedGoogle Scholar
  8. 8.
    Delcher, H.K., Fried, M., Shipp, J.C.: Metabolism of lipoprotein lipid in the isolated perfused rat heart. Biochim. Biophys. Acta 106: 10, 1965.PubMedGoogle Scholar
  9. 9.
    Crass, M.F., Meng, H.C.: The removal and metabolism of chylomicron triglycerides by the isolated perfused rat heart: the role of a heparin released lipase. Biochim. Biophys. Acta 125: 106, 1966.Google Scholar
  10. 10.
    Kreisberg, R.A.: Effect of diabetes and starvation on myocardial triglyceride and free fatty acid utilization. Amer. J. Physiol. 210: 379, 1966.PubMedGoogle Scholar
  11. 11.
    Enser, M.B., Kunz, F., Borensztajan, J., Opie, L.H., Robinson, D.S.: Metabolism of triglyceride fatty acids by perfused rat heart. Biochem. J. 104: 306, 1967.Google Scholar
  12. 12.
    Scheur, J., Olson, R.E.: Metabolism of exogenous triglyceride by the isolated perfused rat heart. Amer. J. Physiol. 212: 301, 1967.Google Scholar
  13. 13.
    Schnatz, J.D., Ormsby, J.W., Williams, R.H.: Lipoprotein lipase activity in human heart. Amer. J. Physiol. 205: 401, 1963.PubMedGoogle Scholar
  14. 14.
    Muir, J.R.: The regional production of lipoprotein lipase in man. Clin. Sci. 34: 261, 1968.PubMedGoogle Scholar
  15. 15.
    Carlsten, A., Hallgren, B., Jagenburg, R., Svanborg, A., Werkö, L.: Myocardial metabolism of glucose, lactic acid, amino-acids and fatty acids in healthy human individuals at rest and at different work loads. Scand. J. Clin. Lab. Invest. 13: 418, 1961.PubMedCrossRefGoogle Scholar
  16. 16.
    Keul, J., Doll, E.: The influence of exercise and hypoxia on the substrate uptake of human heart and human skeletal muscles. in Biochemistry of Exercise. Medicine and Sport. Vol. 3, Basel/New York, 1960, p. 41Google Scholar
  17. 17.
    Trout, D.L., Estes, E.H., Friedberg, S.J.: Titration of free fatty acids of plasma: a study of current methods and a new modification. J. Lipid Res. 1: 199, 1960.PubMedGoogle Scholar
  18. 18.
    Kessler, G., Lederer, H.: Fluorometric measurements of triglycerides. in Automation in Analytical Chemistry. New York, 1966, p. 31l.Google Scholar
  19. 19.
    Hjelm, M.: Enzymatic determination of hexoses in blood and urine. Scand. J. Clin. Lab. Invest. 18: suppl. 192, 85, 1966.Google Scholar
  20. 20.
    Lundholm, L., Mohme-Lundholm, E., Vamos, N.: Lactic acid assay with L(+) lactic acid dehydrogenase from rabbit muscle. Acta Physiol. Scand. 58: 1963.Google Scholar
  21. 21.
    Bücher, T., Czok, R., Lamprecht, W., Latzko, E.: Pyruvat. in Metoden der enzymatischen Analyse. Verlag Chemie, Weinheim, 1962, p. 253.Google Scholar
  22. 22.
    Chernick, S.S.: Determimination of glycerol in acyl glycerols. in Methods in Enzymology. Vol. 19. New York, London, 1969, p. 627.CrossRefGoogle Scholar
  23. 23.
    Boberg, J., Carlson, L.A., Freyschuss, U.: Studies on the total and splanchnic turnover of plasma free fatty acids and plasma triglycerides in man by means of isotope and chemical methods. in Progr. Biochem. Pharmacol. Vol. 5. Basel/New York, 1969, p. 149.Google Scholar
  24. 24.
    Boberg, J.: Separation of labeled plasma and tissue lipids by thin-layer chromatography. A quantitative methodological study. Clin. Chim. Acta 14: 325, 1966.PubMedCrossRefGoogle Scholar
  25. 25.
    Holmgren, A., Pernow, B.: Spectrophotometric measurement of orgen saturation of blood in the determination of cardiac output. A comparison with the Van Slyke method. Scand. J. Clin. Lab. Invest. 11: 143, 1959.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • B. W. Lassers
    • 1
    • 2
  • L. Kaijser
    • 1
    • 2
  • M. L. Wahlqvist
    • 1
    • 2
  • L. A. Carlson
    • 1
    • 2
  1. 1.Department of GeriatricsUniversity of UppsalaUppsala
  2. 2.Department of Clinical PhysiologyKarolinska Sjukhuset and King Gustaf V Research InstituteStockholmSweden

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