Glycogen Storage in Human Skeletal Muscle

  • E. Hultman
  • J. Bergström
  • A. E. Roch-Norlund
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 11)


Direct determinations of the glycogen content in skeletal muscle have been performed in numerous animal experiments and detailed studies of the biochemical events in synthesis and breakdown of glycogen in muscle tissue have been performed for many years. Both the intermediate metabolism and the enzyme systems are relatively well established to-day.


Glycogen Store Muscle Glycogen Glycogen Content Human Skeletal Muscle Glucose Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    AHLBORG, B., J. BERGSTRÖM, J. BROHULT, L.-G. EKELUND, and E. HULTMAN. Human muscle glycogen content and capacity for prolonged exercise after different diets. Försvarsmedicin 3: 85–100, 1967.Google Scholar
  2. 2.
    APPLEMAN, M.M., E. BELOCOPITOW, and H.N. TORRES. Factors affecting the activity of muscle glycogen synthetase. Biochem. Biophys. Res. Commun. 14: 550–554, 1964.PubMedCrossRefGoogle Scholar
  3. 3.
    APPLEMAN, M.M. L. BIENBAUMER, and H.N. TORRES. Factors affecting the activity of muscle glycogesynthetase. III. The reaction with adenosine triphosphate, Mg2+, and cyclic 3′5′-adenosine. Arch. Biochem. Biqphys. 116: 39–43, 1966.CrossRefGoogle Scholar
  4. 4.
    BELOCOPITOW, E., M.M. APPLEMAN, and H.N. TORRES. Factors affecting the acvity of muscle glycogen synthe sis. II. The regulation by Ca++, J. Biol. Chem. 240: 3473–3478, 1965.PubMedGoogle Scholar
  5. 5.
    BERGSTRÖM, J. Muscle electrolytes in man. Determined by neutron activation analysis on needle biopsy specimens. A study on normal subjects, kidney patients, and patients with chronic diarrhoea. Scand. J. Clin. Lab. Invest. 14: Suppl. 68, 1962.Google Scholar
  6. 6.
    BERGSTRÖM, J., G. GUARNIERI, and E. HULTMAN. Carbohydrate metabolism and electrolyte changes in human muscle tissue during heavy work. Accepted for publication in J. Appl. Physiol.Google Scholar
  7. 7.
    BERGSTRÖM, J., R.C. HARRIS, E. HULTMAN, and L.-O. NORDESJÖ. Energy rich phosphagens in dynamic and static work. Presented at the Symposium of Muscle Metabolism during Exercise, 6–9 Sept., 1970, Stockholm.Google Scholar
  8. 8.
    BERGSTRÖM, J. and E. HULTMAN. Muscle glycogen synthesis after exercise. An enhancing factor localized to the muscle cells in man. Nature 210: 309–310, 1966.PubMedCrossRefGoogle Scholar
  9. 9.
    BERGSTRÖM, J. and E. HULTMAN. Synthesis of muscle glycogen in man after glucose and fructose infusion. Acta Med. Scand. 182: 93–109, 1967.PubMedCrossRefGoogle Scholar
  10. 10.
    DANFORTH, W.H. Glycogen synthetase activity in skeletal muscle. Interconversion of two forms in the control of glycogen synthesis. J. Biol. Chem. 240: 588–593, 1965.PubMedGoogle Scholar
  11. 11.
    FRIEDMAN, D.L. and J. LARNER. Studies on UDPG-α glucan transglucosylase. III. Interconversion of two forms on muscle UDPG αglucan transglucosylase by a phosphorylation-dephosphorylation reaction sequence. Biochemistry 2: 669–675, 1963.PubMedCrossRefGoogle Scholar
  12. 12.
    HUIJING, F., F.Q. NUTTALL, C. VILLAR-PALASI, and J. LARNER. UDPglucose: α-1, 4-glucanα-4-glucosyltransferase in heart regulation of the activity of the transferase in vivo and in vitro in rat. A dissociation in the action of insulin on transport and on transferase conversion. Biochim. Biophys. Acta 177: 204–212, 1969.PubMedCrossRefGoogle Scholar
  13. 13.
    HULTMAN, E. Studies on muscle metabolism of glycogen and active phosphate in man with special reference to exercise and diet. Scand. J. Clin. Lab. Invest. 19: Suppl. 94, 1967.Google Scholar
  14. 14.
    HULTMAN, E. Muscle glycogen stores and prolonged exercise. In: Frontiers of Fitness.Ed: R.J. SHEPHARD. Toronto, Canada: The Canadian Asssociation of Sports Science, 1970.Google Scholar
  15. 15.
    HULTMAN, E. and J. BERGSTRÖM. Muscle glycogen synthesis in relation to diet studied in normal subjects. Acta Med. Scand. 182: 109–117, 1967.PubMedCrossRefGoogle Scholar
  16. 16.
    LAMB, D.R., J.B. PETER, R.N. JEFFRESS, and H.A. WALLACE. Glycogen, hexokinase, and glycogen synthetase adaptations to exercise. Am. J. Physiol. 217: 1628–1632, 1969.PubMedGoogle Scholar
  17. 17.
    NARAHARA, H.T. and C.F. CORI. Hormonal control of carbohydrate metabolism in muscle. In: Carbohydrate Metabolism and its Disorders. Eds: F. DICKENS, P.J. RANDLE, and W.J. WHELAN. London and New York: Academic Press. 1: 375–395, 1968.Google Scholar
  18. 18.
    PETER, J.B., R.N. JEFFRESS, and D.R. LAMB. Exercise-effects on hexokinase activity in red and white skeletal muscle. Science 160: 200–201, 1968.PubMedCrossRefGoogle Scholar
  19. 19.
    PIRAS, R., L.B. ROTHMAN, and E. CABIB. Regulation of muscle glyoogen synthetase by metabolites, differential effects on the I and D forms. Biochemisty 7: 56–66, 1968.CrossRefGoogle Scholar
  20. 20.
    PIRAS, R. and R. STANELONI. In vivo regulation of rat muscle glycogen synthetase activity. Biochemistry 8: 2153–2160, 1969.PubMedCrossRefGoogle Scholar
  21. 21.
    ROCH-NORLUND, A.E., J. BERGSTRÖM, H. CASTENFORS, and E. HULTMAN. Muscle glycogen in patients with diabetes mellitus. Glycogen content before treatment and the effect of insulin. Acta Med. Soand. 187: 445 453, 1970.Google Scholar
  22. 22.
    ROSELL-PEREZ, M. and J. LARNER. Studies on UDPG-α-glucan transglucosylase. IV. Purification and characterization of two forms from rabbit skeletal muscle. V. Two forms of the enzyme in dog skeletal muscle and their interconversion. Biochemistry 3: 75–88, 1964.PubMedCrossRefGoogle Scholar
  23. 23.
    STADIE, W.C., N. HAUGAARD, and M. VAUGHAN. Quantitative relation between insulin and its biological activity. J. Biol. Chem. 200: 745–751, 1953.PubMedGoogle Scholar
  24. 24.
    STANELONI, R. and R. PIRAS. Changes in glycogen synthetase and phosphorylase during muscular contraction. Biochem. Biophys. Res. Commu.n. 36: 1032–1038, 1969.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • E. Hultman
    • 1
  • J. Bergström
    • 1
  • A. E. Roch-Norlund
    • 1
  1. 1.Department of Clinical ChemistryS:t Eriks SjukhusStockholmSweden

Personalised recommendations