Abstract
Muscle’s primary function is contraction, but thanks to its relatively great mass and protein content, it serves several vital metabolic roles. It is a most important buffer to acid-base alterations and even changes its own metabolic reactions as a response to increases or decreases in hydrogen ion concentration. It also serves as a buffer to other ion changes, such as potassium or magnesium. Less emphasized has been its role as the body’s principie nitrogen reservoir, or more accurately, as the body’s depot of substrate for gluconeogenesis. This brief note addresses itself to this last point.
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References
Waterlow, J. C. and Stephen, J. M. L. The measurement of total lysine turnover in the rat by intravenous infusion of L-(U-14C) lysine. Clin. Sci. 33: 489, 1967.
Waterlow, J. C. Lysine turnover in man measured by intravenous infusion of L-(U-14C)lysine. Clin. Sci. 33: 507, 1967.
Garlick, P. J. Measurement of muscle protein turnover by constant intravenous infusion of (14C)glycine. Biochem. J. 113: 7p 1970.
Carlsten, A., Hallgren, B., Jagenburg, R., Svanborg, A. and Werko, L. Arterio-hepatic venous differences of free fatty acids and amino acids. Acta Med. Scand. 181: 199, 1967.
Pozefsky, T., Felig, P., Tobin, J. D. Soeldner, J. S. and Cahill, G. F. Jr. Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels. J. Clin. Invest. 48: 2273, 1969.
Felig, P., Pozefsky, T., Marliss, E. and Cahill, G. F. Jr. Alanine-key role in gluconeogenesis. Science 167: 1003, 1970.
Cahill, G. F. Jr. and Owen, O. E. Some observations on carbohydrate metabolism in man in Carbohydrate Metabolism and its Disorders: Chapt 16. Dickens, F., Randle, P. J. and Whelan, W. J. eds 1968 Academic Press, London pp 497–522
Owen, O. E. Felig, P., Morgan, A. P., Wahren, J. and Cahill, G. F. Jr. Liver and Kidney metabolism during prolonged starvation. J. Clin. Invest. 48: 574, 1969.
Felig, P., Owen, O. E., Wahren, J. and Cahill, G. F. Jr. Amino acid metabolism during prolonged starvation. J. Clin. Invest. 48: 584, 1969.
Owen, O. E. Morgan, A. P., Kemp, H. C., Sullivan, J. M., Herrera, M. G. and Cahill, G. F. Jr. Brain metabolism during fasting. J. Clin. Invest. 46: 1589, 1967.
Owen, O. E. and Reichard, G. A. Jr. Substrate extraction and/or production by forearm muscle during progressive starvation. Clin. Research 18: 461, 1970
Lotspeich, W. The role of insulin in the metabolism of amino acids. J. Biol. Chem. 179: 175, 1949.
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© 1971 Plenum Press, New York
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Cahill, G.F. (1971). Metabolic Role of Muscle. In: Pernow, B., Saltin, B. (eds) Muscle Metabolism During Exercise. Advances in Experimental Medicine and Biology, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4609-8_10
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DOI: https://doi.org/10.1007/978-1-4613-4609-8_10
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