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Multiple Measures of Compensatory Adaptation in Catecholamine Biosynthesis

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New Concepts in Neurotransmitter Regulation

Abstract

It has become apparent that the in vivo rate of catecholamine synthesis is subject to control by a variety of factors. The first such regulating influence to be described, and probably the most important, was the acute effect of sympathetic nerve activity on the catecholamine synthetic rate. Work from a number of different laboratories has demonstrated that changes in sympathetic tone result in an immediate and corresponding alteration of the rate of catecholamine synthesis (Alousi and Weiner, 1966; Gordon et al., 1966; Sedvall and Kopin, 1967; Dairman and Udenfriend, 1970 a). Evidence has been presented that the activity of tyrosine hydroxylase, the rate limiting enzyme in catecholamine synthesis (Levitt et al., 1965), is being reversibly modified through a mechanism thought to involve end-product inhibition by catecholamines (Alousi and Weiner, 1966; Neff and Costa, 1966; Spector et al., 1967). This occurs without an actual change in the level of tyrosine hydroxylase enzyme (Dairman et al., 1968).

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Authors and Affiliations

  1. Roche Institute of Molecular Biology, Nutley, New Jersey, USA

    Wallace Dairman

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  1. Wallace Dairman
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Editors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, California, USA

    Arnold J. Mandell

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Dairman, W. (1973). Multiple Measures of Compensatory Adaptation in Catecholamine Biosynthesis. In: Mandell, A.J. (eds) New Concepts in Neurotransmitter Regulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4574-9_1

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  • DOI: https://doi.org/10.1007/978-1-4613-4574-9_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4576-3

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