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Studies on the Primary Structure of Human Secretory Component

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The Immunoglobulin a System

Abstract

Secretory component occurs in external secretions in two forms, bound and free. The former is an integral part of the secretory IgA molecule, the attachment being covalent in the human. Free secretory component, on the other hand, is present in secretions unattached to other protein. The bound and free forms of secretory component, in both human (1,2) and rabbit (3) have been previously compared in terms of size, amino acid composition, and antigenic determinants and found to be similar, and possibly identical. In order to extend the comparison of the bound vs. free secretory component we have done peptide mapping studies and determined their N-terminal amino acid sequences.

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References

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Author information

Authors and Affiliations

  1. New York University Medical Center, 10016, New York, New York, USA

    Charlotte Cunningham-Rundles, Michael E. Lamm & Edward C. Franklin

Authors
  1. Charlotte Cunningham-Rundles
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  2. Michael E. Lamm
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  3. Edward C. Franklin
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Editor information

Editors and Affiliations

  1. Institute of Dental Research Departments of Microbiology and Medicine, University of Alabama in Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky

  2. Departments of Pediatrics and Microbiology, University of Alabama in Birmingham, Birmingham, Alabama, USA

    Alexander R. Lawton

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© 1974 Plenum Press, New York

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Cunningham-Rundles, C., Lamm, M.E., Franklin, E.C. (1974). Studies on the Primary Structure of Human Secretory Component. In: Mestecky, J., Lawton, A.R. (eds) The Immunoglobulin a System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4550-3_28

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  • DOI: https://doi.org/10.1007/978-1-4613-4550-3_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4552-7

  • Online ISBN: 978-1-4613-4550-3

  • eBook Packages: Springer Book Archive

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