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Aspirin and Prostaglandins

  • S. H. Ferreira
  • J. R. Vane

Abstract

Inflammation has been investigated by workers from many disciplines, including biochemistry, immunology, pathology, and pharmacology. Each discipline brings its own techniques and philosophy to the study; thus pharmacologists have searched for chemical mediators of the inflammatory response, whereas pathologists have concentrated on the cellular aspects. Only now is a general and unified view of inflammation emerging; this coalescence of view has been stimulated by the discovery that nonsteroid anti-inflammatory drugs inhibit the biosynthesis of prostaglandins. This discovery revealed what seems likely to be the main mechanism of action of aspirin-like drugs and incidentally, but importantly, provided a valuable and simple tool for exploring the involvement of prostaglandins in other pathological and physiological processes.

Keywords

Renal Blood Flow Prostaglandin Synthesis Prostaglandin Production Prostaglandin Biosynthesis Prostaglandin Synthetase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • S. H. Ferreira
    • 1
  • J. R. Vane
    • 1
  1. 1.Wellcome Research LaboratoriesLangley CourtBeckenham, KentEngland, UK

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