Abstract
The poly(A) sequences covalently bound both to the heterogeneous RNA (HnRNA) of the nucleus and to the polysome-bound messenger RNA (mRNA) of many eukaryotes (1–3) have provided chemical evidence for the precursor- product relationship long predicted to link these two species of RNA. In addition to permitting new studies of the biogenesis of mRNA in eukaryotes, the poly(A) sequences have provided the basis for techniques for the isolation and purification of both of these classes of heterogeneous RNA molecules. These techniques have allowed us to examine the location and the size of the poly(A) sequences within RNA molecules and to estimate both the number of poly(A) sequences per molecule and the fraction of mRNA and HnRNA molecules that contain poly(A) sequences. Some HnRNA molecules that contain poly(A) sequences have been compared with those that do not.
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© 1974 Plenum Press, New York
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Nakazato, H., Edmonds, M. (1974). The Poly(A) Sequences in Messenger RNA and Heterogeneous Nuclear RNA. In: Biswas, B.B., Mandal, R.K., Stevens, A., Cohn, W.E. (eds) Control of Transcription. Basic Life Sciences, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4529-9_25
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DOI: https://doi.org/10.1007/978-1-4613-4529-9_25
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