Experimental Epilepsy: Cerebro-Cerebellar Interactions and Antiepileptic Drugs

  • Robert M. Julien


Epilepsy is a term used to describe the repeated occurrence of any of the various clinical forms of convulsive seizures. Convulsive seizures appear to be the normal mode of expression of cerebral cortex and subcortical structures to an excessive, overwhelming discharge originating in a variety of loci. The tonic extensor rigidity and clonic convulsive movements of the clinical grand mal attack result from involvement of motor cortex and the spread of excitation away from the abnormal focal discharge (Adrian, 1936). One fundamental problem in epilepsy involves identification of the mechanism underlying and controlling the “highly explosive” discharges described by Kughlings Jackson (1931) which characterize the cortical epileptic focus (Ward, 1969).


Purkinje Cell Cerebellar Cortex Antiepileptic Action Dentate Nucleus Cortical Excitability 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Robert M. Julien
    • 1
  1. 1.Department of Medical Pharmacology and TherapeuticsUniversity of California at IrvineIrvineUSA

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