Dependence of Action Potential Parameters on the Constants of Membrane Ionic Permeability
It follows from the examination of the kinetics of the ionic currents accompanying the nervous impulse that all factors inhibiting the increase in sodium permeability must increase the critical level of depolarization and reduce the rate of rise and the amplitude of the action potential. Slowing of sodium inactivation or inhibition of potassium activation, on the other hand, must be accompanied by prolongation of the descending phase of the spike without any appreciable changes in its other parameters.
KeywordsPermeability Nickel Depression Cocaine CaCl
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