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Assays of Hypothalamic Releasing and Inhibiting Hormones

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Research Methods in Neurochemistry

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Abstract

It is firmly established that the secretory activity of the pituitary gland is regulated by the hypothalamus of the brain by means of the releasing and inhibiting hormones which are elaborated by the nerve cells in the hypothalamus and transported to the pituitary via the hypophyseal portal vessels. The secretion of each of the six adenohypophyseal hormones (ACTH, TSH, LH, FSH, GH, and prolactin) and the hormone of the intermediate lobe of pituitary (MSH) is controlled by the respective hypothalamic regulating hormone(s). The release of ACTH, TSH, LH, FSH, and GH is under the control of stimulatory influence of the releasing hormones, whereas the secretion of prolactin and MSH is mainly under a tonic control by the inhibitory hormones. In addition, the secretion of prolactin and MSH appears to be regulated by their releasing hormones, and GH by the release-inhibiting hormone (Schally et al., 1973a).

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Authors and Affiliations

  1. Department of Medicine, Tulane University School of Medicine, and Veterans Administration Hospital, New Orleans, Louisiana, 70112, USA

    Akira Arimura & Andrew V. Schally

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  1. Akira Arimura
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  2. Andrew V. Schally
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Editors and Affiliations

  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, New York, USA

    Neville Marks

  2. Department of Biochemistry, Institute of Psychiatry University of London, London, Great Britain

    Richard Rodnight

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© 1975 Plenum Press, New York

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Arimura, A., Schally, A.V. (1975). Assays of Hypothalamic Releasing and Inhibiting Hormones. In: Marks, N., Rodnight, R. (eds) Research Methods in Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4458-2_12

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  • DOI: https://doi.org/10.1007/978-1-4613-4458-2_12

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