Genetic Influences in Human Tumors
Although the genetic analysis of cancer in animals has played a major role in the development of knowledge and new ideas about the etiology and pathogenesis of cancer, the genetic study of human cancer has played a very minor role. Part of this difference is attributable to the fact animal data have been provided to a great extent by experimental manipulation of selected species and genetic strains, whereas human data have been largely descriptive and not related either to animal data or to critical etiological hypotheses. Genetic analyses of human cancer have consisted primarily of population, family, and twin studies of tumor occurrence and cytogenetic analyses. The results of cytogenetic analyses of human tumors are thoroughly discussed elsewhere in this volume, and reference to them in this chapter will be confined largely to discussion of genetically predisposing conditions which involve chromosomal abnormality. It is the study of the occurrence of tumors that has contributed most significantly to the understanding of etiology.
KeywordsLymphoma Leukemia Adenocarcinoma Hydrocarbon Adenoma
Unable to display preview. Download preview PDF.
- Anderson, D. E., 1970, Genetic varieties of neoplasia, in: Genetic Concepts and Neoplasia (M. D. Anderson Hospital Symposium), pp. 85–109, Williams and Wilkins, Baltimore.Google Scholar
- German, J., 1972, Genes which increase chromosomal instability in somatic cells and predispose to cancer. Prog. Med. Genet. 8: 61.Google Scholar
- Higurashi, M., and Conen, P. E., 1971, In vitro chromosomal radiosensitivity in Fanconi’s anemia. Blood 38: 336.Google Scholar
- Hirschhorn, K., and Blogh-Shtagher, N., 1970, Transformation of genetically abnormal cells, in: Genetic Concepts and Neoplasia (M. D., Anderson Hospital Symposium), pp. 191–202, Williams and Wilkins, Baltimore.Google Scholar
- Knudson, A. G., and Strong, L. C., 1972a, Mutation and cancer: Neuroblastoma and pheochromocytoma, Am. J. Hum. Genet. 24: 514.Google Scholar
- Knudson, A. G., and Strong, L. C., 1972b, Mutation and cancer: A model for Wilms’ tumor of the kidney, J. Natl. Cancer Inst. 48: 313.Google Scholar
- Neel, J. V., 1962, Mutations in the human population, in: Methodology in Human Genetics ( W. J. Burdette, ed.), pp. 203–224, Holden-Day, San Francisco.Google Scholar
- Nowell, P. C., and Hungerford, D. A., 1960, A minute chromosome in human chronic granulocytic leukemia. Science 132: 1497.Google Scholar
- Strong, L. C., and Knudson, A. G., 1972, Mutation and childhood cancer: A model and its implications. Am. J. Hum. Genet. 24: 48a.Google Scholar
- Warthin, A. S., 1913, Heredity with reference to carcinoma: As shown by the study of the cases examined in the pathological laboratory of the University of Michigan, 1895–1913, Arch. Int. Med. 12: 546.Google Scholar