Abstract
Ionizing radiation in sufficiently high dosage acts as a complete carcinogen in that it serves as both initiator and promoter. Further, cancers can be induced in nearly any tissue or organ of man or experimental animals by the proper choice of radiation dose and exposure schedule. Principal interest in radiation as an environmental carcinogen is not at very high dosage levels, however, since relatively few individuals receive such high dosages and in most cases where they do the radiation is received as localized treatment for a malignant tumor. Additionally, radiation delivered to the entire body, as is usually the case for environmental exposure, is acutely fatal (within weeks) at doses higher than a few hundred rads. For these reasons, the major goal of studies on radiation as a carcinogen is the determination of its cancerogenic effectiveness in the extremely low to moderate dosage range. Because radiation can be easily delivered in precisely measured quantities and because it is a fairly potent carcinogen, it has also been widely used as an experimental tool in cancer research.
Research sponsored by the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albert, R. E., and Omran, A. R., 1968, Follow-up study of patients treated by X-ray epilation for tinea capitis. 1. Population characteristics, post-treatment illnesses, and mortality experience, Arch. Environ. Health 17: 899.
Bair, W. J., 1970, Inhalation of radionuclides and carcinogenesis, in: Inhalation Carcinogenesis (P. Nettesheim, M. G. Hanna, Jr., and J. R. Gilbert, eds.), pp. 77–97, USAEC Division of Technical Information, Symposium Series 18, National Technical Information Service, Springfield, Va., CONF-691001.
Beebe, G. W., Kato, H., and Land, C. E., 1971, Studies on the mortality of A-bomb survivors. 4. Mortality and radiation dose, 1950–1966, Radiation Res. 48: 613.
Belsky, J. L., Tachikawa, K., Cihak, R. W., and Yamomoto, T., 1972, Salivary gland tumors in atomic bomb survivors, Hiroshima-Nagasaki, 1957 to 1970, JAMA 219: 864.
Berenblum, I., 1941, The mechanism of carcinogenesis: A study of the significance of carcinogenic action and related phenomena. Cancer Res. 1: 807.
Berenblum, I., Chen, L., and Trainin, N., 1968, A quantitative study of the leukemogenic action of whole-body x-irradiation and urethane, Israel J. Med. Sci. 4: 1159.
Bloch, C., 1962, Osteogenic sarcoma: Report of a case and review of literature. Am. J. Roentgenol. 87: 1157
Braestrup, C. B., 1957, Past and present radiation exposure to radiologists from the point of view of life expectancy. Am. J. Roentgenol. 78: 988.
Bross, I. D. J., and Natarajan, N., 1972, Leukemia from low level radiation. New Engl. J. Med. 287: 107.
Brown, D. G., Johnson, D. F., and Cross, F. H., 1965, Late Effects observed in burros surviving external whole-body gamma irradiation. Radiation Res. 25: 574.
Burns, F. J., Albert, R. E., and Heimbach, R. D., 1968, RBE for skin tumors and hair follicle damage in the rat following irradiation with alpha particles and electrons. Radiation Res. 36: 225.
Cole, L. J., and Foley, W. A., 1969, Modification of urethan-lung tumor incidence by low x-radiation doses, cortisone and transfusion of isogenic lymphocytes, Radiation Res. 39: 391.
Conrad, R. A., Dobyns, B. M., and Sutow, W. W., 1970, Thyroid neoplasia as late effect of exposure to radioactive iodine in fallout, JAMA 214: 316.
Court Brown, W. M., and Doll, R., 1958, Expectation of life and mortality from cancer among British radiologists, Brit. Med. J. 2: 181.
Court Brown, W. M., and Doll, R., 1965, Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis, Brit. Med. J. 2: 1327.
Court Brown, W. M., Doll, R., and Hill, A. B., 1960, Incidence of leukemia after exposure to diagnostic radiation in utero, Brit. Mid. J. 2: 1539.
Diamond, E. L., 1968, Unpublished studies. Cited by Kessler, I. L, and Lilienfeld, A. M., 1969, Perspectives in the epidemiology of leukemia, in: Advances in Cancer Research, Vol. 12 ( G. Klein and S. Weinhouse, eds.), pp. 225–302, Academic Press, New York.
Doll, R., and Smith, P. G., 1968, The long-term effects of x irradiation in patients treated for metropathia haemorrhagica, Brit. J. Radiol. 41: 362.
Dougherty, T. F., and Mays, C. W., 1969, Bone cancer induced by internally-deposited emitters in beagles, in: Radiation-Induced Cancer, pp. 361–367, IAEA, Vienna.
Dublin, L.L, and Spiegelman, M., 1948, Mortality of medical specialists 1938–1942, JAMA 137: 1519.
Epstein, J. H., 1972, Examination of the carcinogenic and cocarcinogenic effects of Grenz radiation. Cancer Res. 32: 2625.
Evans, R. D., Keane, A. T., Kolenkow, R. J., Neal, W. R., and Shanahan, M. M., 1969, Radiogenic tumors in the radium and mesothorium cases studied at M.I.T., in: Delayed Effects of Bone-Seeking Radionuclides ( C. W. Mays, W. S. S. Jee, R. D. Lloyd, B. J. Stover, J. H. Dougherty, and G. N. Taylor, eds.), pp. 157–194, University of Utah Press, Salt Lake City.
Evans, R. D., Keane, A. T., and Shanahan, M. M., 1972, Radiogenic effects in man of long-term skeletal alpha-irradiation, in: Radiobiology of Plutonium ( B. J. Stover and W. S. S. Jee, eds.), pp. 431–468, The J. W. Press, Salt Lake City.
Finkel, M. P., and Biskis, B. O., 1962, Toxicity of plutonium in mice. Health Phys. 8: 565.
Finkel, M. P., Biskis, B. O., and Jinkins, P. B., 1969, Toxicity of radium-226 in mice, in: Radiation-Induced Cancer, pp. 369–391, IAEA, Vienna.
Furth, J., Upton, A. C., and Kimball, A. W., 1959, Late pathologic effects of atomic detonation and their pathogenesis. Radiation Res. Suppl. 1: 243.
Gibson, R. W., Bross, I. D. J., Graham, S., Lilienfeld, A. M., Schuman, L. M., Levin, M. L., and Dowd, J. E., 1968, Leukemia in children exposed to multiple risk factors. New Engl. J. Med. 279: 906.
Grahn, D., Fry, R. J. M., and Lea, R. A., 1972, Analysis of survival and cause of death statistics for mice under single and duration-of-life gamma irradiation, in: Life Sciences and Space Research, Vol. X ( A. C. Strickland, ed.), Akademie-Verlag, Berlin.
Griem, M. D., Meier, P., and Dobben, G. D., 1967, Analysis of the morbidity and mortality of children irradiated in fetal life. Radiology 88: 347.
Hazen, R. W., Pifer, J. W., Tayooka, T., Livengood, J., and Hempelmann, L. H., 1966, Neoplasms following irradiation of the head, Cancer Res. 26: 305.
Hempelmann, L. H., Pifer, J. W., Burke, G. W., Terry, R., and Ames, W. R., 1967, Neoplasms in persons treated with X-rays in infancy for thymic enlargement: A report of third follow-up survey, J. Natl. Cancer Inst. 38: 317.
Hoel, D. G., and Walburg, H. E., Jr., 1972, Statistical analysis of survival experiments, J. Natl. Cancer Inst. 49: 361.
Hug, O., Gössner, W., Müller, W. A., Luz, A., and Hindringer, B., 1969, Production of osteosarcomas in mice and rats by incorporation of radium-224, in: Radiation-Induced Cancer, pp. 393–409, IAEA, Vienna.
Hulse, E. V., 1967, Incidence and pathogenesis of skin tumors in mice irradiated with single external doses of low energy beta particles, Brit. J. Cancer 21: 531.
Hutchison, G. B., 1968, Leukemia in patients with cancer of the cervix uteri treated with radiation: A report covering the first 5 years of an international study, J. Natl. Cancer Inst. 40: 951.
International Commission on Radiological Protection, 1969, Publication 14: Radiosensitivity and Spatial Distribution of Dose, Pergamon Press, Oxford.
Ishimaru, T., Hoshino, T., Ichimaru, M., Okada, H., Tomiyasu, T., Tsuchimoto, T., and Yamamoto, T., 1971, Leukemia in atomic bomb survivors, Hiroshima and Nagasaki, 1 October 1950–30 September 1966, Radiation Res. 45: 216.
Jablon, S., and Kato, H., 1970, Childhood cancer in relation to prenatal exposure to atomic-bomb radiation. Lancet 2: 1000.
Jablon, S., and Kato, H., 1972, Studies of the mortality of a-bomb survivors. 5. Radiation dose and mortality, 1950–1970, Radiation Res. 50: 649.
Johnson, M. L. T., Land, C. E., Gregory, P. B., Taura, T., and Milton, R. C., 1969, Effects of Ionizing Radiation on the Skin, Hiroshima-Nagasaki, ABCC TR 20-69.
Kaplan, H. S., 1948, Influence of age on susceptibility of mice to the development of lymphoid after irradiation, J. Natl. Cancer Inst. 9: 55.
Kaplan, H. S., 1958, An evaluation of the somatic and genetic hazards of the medical uses of radiation. Am. J. Roentgenol. 80: 696.
Kellerer, A. M., and Rossi, H. H., 1972, The theory of dual radiation action, Curr. Topics Radiation Res. Quart. 8: 85.
Lewis, T. L. T., 1960, Leukemia in childhood after antenatal exposure to X-rays, Brit. Med. J. 2: 1551.
Lindop, P. J., and Rotblat, J., 1962, The age factor in the susceptibility of man and animals to radiation, 1. The age factor in radiation sensitivity in mice, Brit. J. Radiol. 35: 23.
Lindop, P. J., and Rotblat, J., 1966, Induction of lung tumors by the action of radiation and urethane, Nature (Lond.) 210: 1392.
Lindsay, S., and Chaikoff, 1964, The effects of irradiation on the thyroid gland with particular reference to the induction of thyroid neoplasms: A review. Cancer Res. 24: 1099.
Lundin, F. E., Jr., Wagoner, J. K., and Archer, V. E., 1971, Radon Daughter Exposure and respiratory Cancer: Quantitative and Temporal Aspects, Report from the epidemiological study of United States uranium miners, NIOSH-NIEHS Joint Monograph No. 1., U.S. Public Health Service, National Technical Information Service, Springfield, Va., P.B. 204–871.
Mackenzie, L, 1965, Breast cancer following multiple fluoroscopies, Brit. J. Cancer 19: 1.
MacMahon, B., 1962, Prenatal x ray exposure and childhood cancer, J. Natl. Cancer Inst. 28: 1173.
MacMahon, B., and Hutchison, G. B., 1964, Prenatal x-ray and childhood cancer: A review. Acta Unio. Int. Contra Cancrum 20: 1172.
Maldague, P., 1969, Comparative study of experimentally induced cancer of the kidney in mice and rats with x-rays, in: Radiation-Induced Cancer, pp. 439–458, IAEA, Vienna.
Manning, M. D., and Carroll, B. E., 1957, Some epidemiological aspects of leukemia in children, J. Natl. Cancer Inst. 19: 1087.
Mays, C. W., and Lloyd, R. D., 1972a, Bone sarcoma risk from 90Sr, in: Biomedical Implications of Radiostrontium Exposure (M. Goldman and L. K. Bustad, eds.), pp. 352–370, USAEC Division of Technical Information, Symposium Series 25, National Technical Information Service, Springfield, Va.,CONF-71020L
Mays, C. W., and Lloyd, R. D., 19726, Bone sarcoma incidence vs. alpha particle dose, in: Radiobiology of Plutonium (B. J. Stover and W. S. S. Jee, eds.), pp. 409–430, The J. W. Press, Salt Lake City.
Mettler, F. A., Hempelmann, L. H., Button, A. M., Pifer, J. W., Toyooka, E. T., and Ames, W. R., 1969, Breast neoplasms in women treated with X-rays for acute post-partum mastitis: A pilot study, J. Natl. Cancer Inst. 43: 803.
Myrden, J. A., and Hiltz, J. E., 1969, Breast cancer following multiple fluoroscopies during artificial pneumothorax treatment of pulmonary tuberculosis, Canad. Med. Assoc. J. 100: 1032.
National Academy of Sciences-National Research Council, 1972, The Effects on Populations of Exposure to Low Levels of Ionizing Radiation, Report of the Advisory Committee on the Biological Effects of Ionizing Radiations, Washington, D.C.
Nilsson, A., 1970, Pathologic effects of different doses of radiostrontium in mice: Dose effect relationship in 90Sr-induced bone tumors, Acta Radiol. Ther. Phys. Biol. 9: 155.
Pifer, J. W., Hempelmann, L. H., Dodge, H. J., and Hodges, F. J. N, 1968, Neoplasms in the Ann Arbor series of thymus irradiated children; a second survey, Am. J. Roentgenol. Radium Ther. Nuclear Med. 103: 13.
Rugh, R., Duhamel, L., and Skaredoff, L., 1966, Relation of embryonic and fetal x irradiation to life time average weights and tumor incidence in mice, Proc. Soc. Exp. Biol. Med. 121: 714.
Saenger, E. L., Silverman, F. N., Sterling, T. D., and Turner, M. E., 1960, Neoplasia following therapeutic irradiation for benign conditions in childhood. Radiology 74: 889.
Saenger, E. I., Silverman, F. N., Sterling, T. D., and Turner, M. E., 1960, Neoplasia following therapeutic irradiation for benign conditions in childhood, Radiology 74: 889.
Schulz, R. J., and Albert, R. E., 1968, HI. Dose to organs of the head from the X-ray treatment of dnea capids. Arch. Environ. Health 17: 935.
Segaloff, A., and Maxfield, W. S., 1971, The synergism between radiation and estrogen in the production of mammary cancer in the rat. Cancer Res. 31: 168.
Seltser, R., and Sartwell, P. E., 1965, The influence of occupational exposure to radiation on the mortality of American radiologists and other medical specialists, Am. J. Epidemiol. 81: 2.
Shellabarger, C. J., and Brown, R. D., 1972, Rat mammary neoplasia following irradiation at 0.03 R or 10 R per minute. Radiation Res. 51: 493.
Shellabarger, C. J., and Straub, R., 1972, Effect of 3-methylcholanthrene and fission neutron irradiation, given singly or combined, on rat mammary carcinogenesis, J. Natl. Cancer Inst. 48: 185.
Shellabarger, C. J., Bond, V. P., Cronkite, E. P., and Aponte, G. E., 1969, Relationship of dose of total-body 60Co radiation to incidence of mammary neoplasia in female rats, in: Radiation-Induced Cancer, pp. 161–172, IAEA, Vienna.
Shubik, P., Goldfarb, A. R., Ritchie, A. C., and Lisco, H., 1953, Latent carcinogenic action of beta-irradiation on mouse epidermis, Nature (Lond.) 171: 934.
Spiess, H., and Mays, C. W., 1970, Bone cancers induced by 224Ra(ThX) in children and adults. Health Phys. 19: 713.
Spiess, H., and Mays, C. W., 1971, Erratum, Health Phys. 20: 543.
Steinitz, R., 1965, Pulmonary tuberculosis and carcinoma of the lung, Am. Rev. Resp. Dis. 92: 758.
Stewart, A., 1961, Aetiology of childhood malignancies, Brit. Med. J. 1: 452.
Stewart, A., and Kneale, G. W., 1968, Changes in the cancer risk associated with obstetric radiography, Lancet 1: 104.
Stewart, A., and Kneale, G. W., 1970, Radiation dose effects in relation to obstetric X-rays and childhood cancers, Lancet 1: 1185.
Stewart, A., Webb, J., and Hewitt, D., 1958, A survey of childhood malignancies, Brit. Med. J. 1: 1495.
Storer, J. B., 1973, Unpublished data.
Telles, N. C., Ward, B. C., Willensky, E. A., and Jessup, G. L., 1969, Radiation-ethionine carcinogenesis, in: Radiation-Induced Cancer, pp. 233–245, IAEA, Vienna.
United Nations, 1972, Ionizing Radiation: Levels and Effects, Vol. II: Effects, Report of the United Nations Scientific Committee on the Effects of Atomic Radiation, United Nations, New York.
Upton, A. C., 1964, Comparative aspects of carcinogenesis by ionizing radiation, Natl. Cancer Inst. Monogr. 14: 221.
Upton, A. C., and Cosgrove, G. E., 1968, Radiation induced leukemia, in: Experimental Leukemia ( M. Rich, ed.), pp. 131–158, Appleton-Century-Crofts, New York.
Upton, A. C., Odell, T. T., Jr., and Sniffen, E. P., 1960, Influence of age at time of irradiation on induction of leukemia and ovarian tumors in RF mice, Proc. Soc. Exp. Biol. Med. 104: 769.
Upton, A. C., Wolff, F. F., and Sniffen, E. P., 1961, Leukemogenic effect of myleran on the mouse thymus, Proc. Soc. Exp. Biol. Med. 108: 464.
Upton, A. C., Jenkins, V. K., and Conklin, J. W., 1964, Myeloid leukemia in the mouse, Ann. N.Y. Acad. Sci. 114 (1): 189.
Upton, A. C., Conklin, J. W., and Popp, R. A., 1966, Influence of age at irradiation on susceptibility to radiation-induced life-shortening in RF mice, in: Radiation and Ageing (P. J. Lindop and G. A. Sacher, eds.), pp. 337–344, Taylor 8c Francis, London.
Upton, A. C., Randolph, M. L., and Conklin, J. W., 1970, Late effects of fast neutrons and gamma-rays in mice as influenced by the dose rate of irradiation: Induction of neoplasia. Radiation Res. 41: 467.
Walburg, H. E., Jr., and Cosgrove, G. E., 1970, Life shortening and cause of death in irradiated germ free mice, in: Proceedings of the First European Symposium on Late Effects of Radiation ( P. Metalli, ed.), pp. 51–67, Comitato Nazionale Energia Nucleare, Roma.
Wanebo, C. K., Johnson, K. G., Sato, K., and Thorslund, T. W., 1968a, Breast cancer after exposure to the atomic bombings of Hiroshima and Nagasaki, New Engl. J. Med. 279: 667.
Wanebo, C. K., Johnson, K. G., Sato, K., and Thorslund, T. W., 19686, Lung cancer following atomic radiation. Am. Rev. Resp. Dis. 98: 778.
Warren, S., 1956, Longevity and causes of death from irradiation in physicians, JAMA 162: 464.
Warren, S., and Gates, O., 1969, Effects of continuous irradiation of mice from conception to weaning, in: Radiation Biology of the Fetal and Juvenile Mammal (M. R. Sikovand D. D. Mahlum, eds.), pp. 419–437, USAEC Technical Information Division, Symposium Series 17, National Technical Information Service, Springfield, Va., CONF-690501.
Wood, J. W., Tamagaki, H., Neriiski, S., Sato, T., Sheldon, W. F., Archer, P. G., Hamilton, H. B., and Johnson, K. G., 1969, Thyroid carcinoma in atomic bomb survivors Hiroshima and Nagasaki, Am. J. Epidemiol. 89: 4.
Yamamoto, T., and Wakabayaski, T., 1968, Bone Tumors Among the Atomic Bomb Survivors of Hiroshima and Nagasaki, ABCC TR 26-68.
Yamamoto, T., Kato, H., Ishida, K., Tahara, E., and McGregor, D. H., 1970, Gastric carcinoma in fixed population, Hiroshima and Nagasaki, Gann 61: 473.
Yuhas, J. M., 1973, Personal communication.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Storer, J.B. (1975). Radiation Carcinogenesis. In: Becker, F.F. (eds) Cancer. A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4449-0_16
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4449-0_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4451-3
Online ISBN: 978-1-4613-4449-0
eBook Packages: Springer Book Archive