FSH-Induction of Androgen Binding Protein in Testes of Sertoli Cell-Only Rats

  • A. R. Means
  • D. J. Tindall
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 2)


Administration of a single dose of FSH to immature rats results in the initiation of a complex series of biochemical events within cells present in testicular seminiferous tubules (1). In order to better define these events in chemically precise terms we have recently developed an animal model in which the tubules are devoid of all germ cells from birth. These Sertoli-cell only animals (SCO) respond to FSH in a manner which is indistinguishable from the effects noted in normal rats (2). Thus, after much indirect evidence the Sertoli cell emerges unequivically as a primary target cell for FSH.


Sertoli Cell Total Nucleic Acid Androgen Binding Protein Testis mRNA Target Cell Activation 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • A. R. Means
    • 1
  • D. J. Tindall
    • 1
  1. 1.Department of Cell BiologyBaylor College of MedicineHoustonUSA

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