Inhibition of Thymidine Incorporation of Tumoral YC8 Cells Cultured in Vitro by Peritoneal Macrophages Activated with Corynebacterium parvum

  • Bernard Halpern
  • Anne-Marie Lorinet
  • Loucas Sparros
  • Antoinette Fray

Abstract

Peritoneal cavity macrophages obtained from animals treated with Corynebacterium parvum inhibited the DNA synthesis of isogenic YC8 tumoral cells present in the culture to a considerable extent. Macrophages from control animals displayed a similar activity, but at a much lower level. Previous x-irradiation of the macrophages did not abolish their inhibitory activity.

Keywords

Lymphoma Cobalt Sarcoma Thymidine Corynebacterium 

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References

  1. Fray, A., Sparros, L., Lorinet, A. M., and Halpern, B. (1975). Nonspecific cytotoxic activity of peritoneal exudate cells against tumoral cells in Corynebacterium parvum-treated animals, in this volume, pp. 181–186.Google Scholar
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Bernard Halpern
    • 1
  • Anne-Marie Lorinet
    • 1
  • Loucas Sparros
    • 1
  • Antoinette Fray
    • 1
  1. 1.Department of Experimental MedicineCollege of FranceParisFrance

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