Riboflavin pp 221-244 | Cite as

Riboflavin Deficiency

  • Grace A. Goldsmith

Abstract

Riboflavin deficiency has been studied in many animal species and always results in failure to grow. This fact might be anticipated in view of the importance of flavoprotein enzymes in cellular metabolism. There have been reported a great variety of lesions, including changes in the skin, loss of hair, degenerative changes in the nervous system and liver, impaired reproduction, and congenital malformations in the offspring. Lesions of the cornea of the eye, cataract formation, and reduced formation of hemoglobin have also been reported. The specificity of some of these lesions has been questioned.

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References

  1. 1.
    Alfrey, C. P., Jr., and Lane, M. 1970. The effect of riboflavin deficiency on erythropoiesis, Seminars Hemat. 7:49–54.Google Scholar
  2. 2.
    Arakawa, T., Mizuno, T., Chiba, F., Sakai, K., Watanabe, S., and Tamura, T. 1968. Frequency analysis of electroencephalograms and latency of photically induced, average evoked responses in children with ariboflavinosis, Tohoku J. Exptl. Med. 94:327–335.CrossRefGoogle Scholar
  3. 3.
    Aykroyd, W. R., Jolliffe, N., Lowry, O. H., Moore, P. E., Sebrell, W. H., Shank, R. E., Tisdall, F. F., Wilder, R. M., and Zamecnik, P. E. 1949. Medical resurvey of nutrition in Newfoundland 1948. Canad. Med. Assn. J. 60:329–352.Google Scholar
  4. 4.
    Aykroyd, W. R., and Krishnan, B. G. 1936. Stomatitis due to vitamin B2 deficiency, Indian J. Med. Res. 24:411–417.Google Scholar
  5. 5.
    Bahr, P. H. 1915. “A report on researches on sprue in Ceylon, 1912–1914,” p. 165, Cambridge University Press, Cambridge, England.Google Scholar
  6. 6.
    Banerjee, B., and Chakrabarti, C. H. 1970. Effect of high cholesterol diet on tissue levels of riboflavin and choline, J. Vitatuinol. 16:235–236.Google Scholar
  7. 7.
    Bessey, O. A., and Wolbach, S. B. 1939. Vascularization of the cornea of the rat in riboflavin deficiency, with a note on corneal vascularization in vitamin A deficiency, J. Exptl. Med. 69:1–12.CrossRefGoogle Scholar
  8. 8.
    Bessey, O. A., Horwitt, M. K., and Love, R. H. 1956. Dietary deprivation of riboflavin and blood riboflavin levels in man, J. Nutr. 58:367–383.Google Scholar
  9. 9.
    Beutler, E. 1969. Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies, J. Clin. Invest. 48:1957–1966.Google Scholar
  10. 10.
    Beyer, R. E., Lamberg, S. L., and Neyman, M. A. 1961. The effect of riboflavin deficiency and galactoflavin feeding on oxidative phosphorylation and related reactions in rat liver mitochondria, Canad. J. Biochem. 39:73–88.Google Scholar
  11. 11.
    Bhat, K. S., and Belavady, B. 1967. Polyunsaturated fatty acid levels in liver and heart of riboflavin deficient rats, Indian J. Biochem. 4:38–40.Google Scholar
  12. 12.
    Bhat, K. S., and Belavady, B. 1970. Effects of riboflavin deficiency and realimentation on essential fatty acid nutritional status of rats, Indian J. Biochem. 7:178–180.Google Scholar
  13. 13.
    Bovina, C., Landi, L., Pasquali, P., and Marchetti, M. 1969. Biosynthesis of folate coenzymes in riboflavin-deficient rats, J. Nutr. 99:320–324.Google Scholar
  14. 14.
    Bro-Rasmussen, F. 1958. The riboflavin requirement of animals and man and associated metabolic relations. Part II: Relation of requirement to the metabolism of protein energy, Nutr. Abst. Rev. 28:369–386.Google Scholar
  15. 15.
    Burch, H. B., Hunter, F. E., Jr., Combs, A. M., and Schutz, B. A. 1960. Oxidative enzymes and phosphorylation in hepatic mitochondria from riboflavin-deficient rats, J. Biol. Chem. 235:1540–1544.Google Scholar
  16. 16.
    Burch, H. B., Lowry, O. H., Padilla, A. M., and Combs, A. M. 1956. Effects of riboflavin deficiency and realimentation on flavin enzymes of tissues, J. Biol. Chem. 223:29–45.Google Scholar
  17. 17.
    Chatterjee, A. K., and Ghosh, B. B. 1967. Effect of riboflavin deficiency on in vivo incorporation of C alanine into liver glycogen, Experientia 23:633–634.CrossRefGoogle Scholar
  18. 18.
    Chatterjee, A. K., and Ghosh, B. B. 1968. Effect of riboflavin deficiency on free amino acid nitrogen concentrations of liver, muscle and plasma, Experientia 24:786–787.CrossRefGoogle Scholar
  19. 19.
    Chatterjee, A. K., Roy, A. K., and Ghosh, B. B. 1969. Effect of riboflavin deficiency on nucleic acid metabolism of liver in the rat, Brit. J. Nutr. 23:657–663.CrossRefGoogle Scholar
  20. 20.
    Chou, S. T., Sell, J. L., and Kondra, P. A. 1971. Interrelationships between riboflavin and dietary energy and protein utilization in growing chicks, Brit. J. Nutr. 26:323–333.CrossRefGoogle Scholar
  21. 21.
    Chou, S. T. Effect of riboflavin deficiency on the metabolism of oxypurines in chicks. 1971. Canad. J. Physiol. Pharmacol. 49:1059–1062.CrossRefGoogle Scholar
  22. 22.
    Consolazio, C. F., Johnson, H.L., Krzywicki, H. J., Daws, T. A., and Barnhart, R. A. 1971. Thiamin, riboflavin and pyridoxine excretion during acute starvation and calorie restriction, Amer. J. Clin. Nutr. 24:1060–1067.Google Scholar
  23. 23.
    Cowan, J. N., Boucher, R. V., and Buss, E. G. 1961. Physiological characteristics associated with mutant gene in chicken that causes deficiency of riboflavin 4. The effect of estrogen, Poultry Science 40:1390.Google Scholar
  24. 24.
    Coward, K. H., and Morgan, B.C. E. 1941. The determination of vitamin B by means of its influence on the vaginal contents of the rat, Biochem. J. 35:974.Google Scholar
  25. 25.
    Deuschle, F. M., Takacs, E., and Warkany, J. 1961. Postnatal dentofacial changes induced in rats by prenatal riboflavin deficiency, J. Dental Res. 40:366–377.CrossRefGoogle Scholar
  26. 26.
    Dixon, M., and Webb, E. C. 1964. “Enzymes,” 2d ed., pp. 405–410, Academic Press, New York.Google Scholar
  27. 27.
    Engel, R. W., Phillips, P. H., and Halpin, J. G. 1940. The effect of a riboflavin deficiency in the hen upon embryonic development of the chick, Poultry Science 19:135.Google Scholar
  28. 28.
    Follis, R. H., 1948. “The Pathology of Nutritional Diseases,” Part IV, p. 159, Charles C Thomas, Springfield, Ill.Google Scholar
  29. 29.
    Foy, H., Kondi, A., and Mbaya, V. 1964. Effect of riboflavin deficiency on bone marrow function and protein metabolism in baboons, Preliminary Report, Brit. J. Nutr. 18:307–318.CrossRefGoogle Scholar
  30. 30.
    Foy, H., and Mbaya, V. 1966. Serum vitamin B1, and folate levels in normal and riboflavin-deficient baboons (papio anubis), Brit. J. Haemat. 12:239–245.CrossRefGoogle Scholar
  31. 31.
    Frei, J., and Ryser, H. 1956. Relations entre oxydation phosphorylante et structure des mitochondries hepatiques de rats carences en vitamintes B et B2 Experientia 12:105–107.CrossRefGoogle Scholar
  32. 32.
    French, S. W. 1966. Effect of chronic ethanol ingestion on liver enzyme changes induced by thiamine, riboflavin, pyridoxine, or choline deficiency, J. Nutr. 88:291–302.Google Scholar
  33. 33.
    Gershoff, S. N., Andrus, S. B., and Hegsted, D. M. 1959. The effect of the carbohydrate and fat content of the diet upon the riboflavin requirement of the cat, J. Nutr. 68:75–88.Google Scholar
  34. 34.
    Glatzle, D., Weber, F., and Wiss, O. 1968. Enzymatic test for the detection of a riboflavin deficiency, NADPH-dependent glutathione reductase of red blood cells and its activation by FAD in vitro,Experientia 24:1122.CrossRefGoogle Scholar
  35. 35.
    Goldberger, J., and Lillie, R. D. 1926. A note on an experimental pellagralike condition in the Albino Rat, U.S. Pub. Health Rept. 41:1025.Google Scholar
  36. 36.
    Goldberger, J., and Tanner, W. F. 1925. A study of pellagra-prevention action of dried beans, casein, dried milk, and brewers yeast, with a consideration of the essential preventive factors involved, U.S. Pub. Health Rept. 40:54–80.Google Scholar
  37. 37.
    Goldsmith, G. A. 1964. The B vitamins: thiamine, riboflavin, niacin. Nutrition: A Comprehensive Treatise, in “Vitamins, Nutrient Requirements, and Food Selection” (G. H. Beaton and E. W. McHenry, eds.), Vol. 2, pp. 153–154, Academic Press, New York.Google Scholar
  38. 38.
    Goldsmith, G. A. 1956. Experimental niacin deficiency in man, J. Amer. Diet. Assoc. 32:312.Google Scholar
  39. 39.
    Goldsmith, G. A. 1943. Incidence and recognition of riboflavin and niacin deficiency in medical diseases, Southern Med. J. 36:108–116 (February).CrossRefGoogle Scholar
  40. 40.
    Goldsmith, G. A. 1945. Nutrition studies in the New Orleans area, Fed. Proc. 4:263–268 (September).Google Scholar
  41. 41.
    Grainger, R. B., O’Dell, B. L., and Hogan, A. G. 1954. Congenital malformations as related to deficiencies of riboflavin and vitamin B 12 source of protein, calcium to phosphorus ratio and skeletal phosphorus metabolism, J. Nutr. 54:33–48.Google Scholar
  42. 42.
    Guggenheim, K., Brzezinski, A., Ilan, J., and Kallner, B. 1959. Nutritional evaluation of flour enrichment with riboflavin in Israel. Amer. J. Clin. Nutr. 7:526–531.Google Scholar
  43. 43.
    Guggenheim, K., and Diamant, E. J. 1959. Body composition of rats in B-vitamin deficiencies, Brit. J. Nutr. 13:61–67.CrossRefGoogle Scholar
  44. 44.
    György, P., Robscheit-Robbins, F. S., and Whipple, G. H. 1938. Lactoflavin (riboflavin) increases hemoglobin production in the anemia dog, Amer. J. Physiol. 122:154.Google Scholar
  45. 45.
    Hara, H. 1960. Pathologic study on riboflavin deficiency in guinea pigs, J. Vitaminol. (Kyoto) 6:24–42.Google Scholar
  46. 46.
    Honda, Y. 1968. Folate derivatives in the liver of riboflavin-deficient rats, Tohoku J. Exptl. Med. 95:79–86.CrossRefGoogle Scholar
  47. 47.
    Horwitt, M. K., Harvey, C. C., Hills, O. W., and Liebert, E. 1950. Correlation of urinary excretion of riboflavin with dietary intake and symptoms of ariboflavinosis, J. Nutr. 41:247–264.Google Scholar
  48. 48.
    Horwitt, M. K., Liebert, E., Kreider, O., and Wittman, P. 1948. Investigations of human requirements for B-complex vitamins, Bull. Natl. Res. Council, No. 116.Google Scholar
  49. 49.
    Hou, H. C. 1949. Nutritional diseases in China, Nutrition Rev. 7:193–195.CrossRefGoogle Scholar
  50. 50.
    Jamdar, S. C., Udupa, K. R., and Chatterji, A. 1968. Study of hematopoiesis in riboflavin deficient rats with 59Fe as tracer, J. Vitamin (Osaka) 14:219–222.Google Scholar
  51. 51.
    Jolliffe, N., Fein, H. D., and Rosenblum, L. A. 1939. Riboflavin deficiency in man, New Eng. J. Med. 221:921–926.CrossRefGoogle Scholar
  52. 52.
    Jusko, W. J., and Levy, G. 1967. Absorption, metabolism and excretion of riboflavin5’-phosphate in man, J. Pharm. Sci. 56:58–62.CrossRefGoogle Scholar
  53. 53.
    Kalter, H. 1959. Congenital malformations induced by riboflavin deficiency in strains of inbred mice, Pediatrics 23:222–230.Google Scholar
  54. 54.
    Kim, Y. S., and Lambooy, J. P. 1967. Riboflavin deficiency and gastric ulcer production in the rat: a procedure for the study of susceptibility to stress-induced gastric ulcers, J. Nutr. 91:183–188.Google Scholar
  55. 55.
    Kunin, C. M., and Finland, M. 1961. Clinical pharmacology of the tetracycline antibiotics, Clin. Pharmacol. Ther. 2:51–69.Google Scholar
  56. 56.
    Lakhanpal, R. K., Harrill, I., and Bowman, F. 1969. Effect of protein and riboflavin on plasma amino acids and hepatic riboflavin-coenzymes, J. Nutr. 99:497–501.Google Scholar
  57. 57.
    Landor, J. V., and Pallister, R. A. 1935. Avitaminosis B2, Trans. Roy. Soc. Trop. Med. Hyg., 29:121–134.CrossRefGoogle Scholar
  58. 58.
    Lane, M., and Alfrey, C. P., Jr. 1965. The anemia of human riboflavin deficiency, Blood 25:432–442.Google Scholar
  59. 59.
    Lane, M., Alfrey, C. P., Jr., Mengel, C. E., Doherty, M. A., and Doherty, J. 1964. The rapid induction of human riboflavin deficiency with galactoflavin, J. Clin. Invest. 43:357–373.CrossRefGoogle Scholar
  60. 60.
    Lane, M., Fahey, J. L., Sullivan, R. D., and Zubrod, C. G. 1958. The comparative pharmacology in man and the rat of the riboflavin analogue 6,7-dimethyl-9-(2’-acetoxyethyl)-isoalloxazine, U-2112, J. Pharmacol. Exptl. Ther. 122:315–326.Google Scholar
  61. 61.
    Leodolter, S., and Genner, M. 1971. Monoamine oxidase activity and norepinephrine content of organs from rats fed on a vitamin BZ deficient diet, Arch. intern. de Pharmacodynamie et de Therapie. 190:393–401.Google Scholar
  62. 62.
    Lipmann, F. 1969. The biochemical function of B vitamins, Perspect. Biol. Med. 13:1–9.Google Scholar
  63. 63.
    Lippincott, S. W., and Morris, H. P. 1941. Morphologic changes associated with pathothenic acid deficiency in the mouse, J. Natl. Cancer Inst. 2:39–46.Google Scholar
  64. 64.
    Luse, S. A., Burch, H. B., and Hunter, F. E., Jr. 1962. Ultrastructural and enzymatic changes in the liver of the riboflavin deficient rat, Intern. Cong. Electron Microscopy, Vol. 5, Academic Press, New York.Google Scholar
  65. 65.
    Mackler, B. 1969. Studies of the molecular basis of congenital malformations, Pediatrics 43:915–926.Google Scholar
  66. 66.
    Mann, G., Watson, P. L., McNally, A., and Goddard, J. 1952. Primate Nutrition. II. Riboflavin deficiency in the cebus monkey and its diagnosis, J. Nutr. 47:225–241.Google Scholar
  67. 67.
    Mason, M. 1953. The metabolism of tryptophan in riboflavin-deficient rats, J. Biol. Chem. 201:513–518.Google Scholar
  68. 68.
    Mickelson, O. 1967. Present knowledge of riboflavin, in “Present Knowledge in Nutrition,” 3rd ed, pp. 61–65, The Nutrition Foundation, Inc., New York.Google Scholar
  69. 69.
    Miller, J. A., Miner, D. L., Rusch, H. P., and Baumann, C. A. 1941. Diet and hepatic tumor formation, Cancer Research 1:699–708.Google Scholar
  70. 70.
    Miller, Z. A., Poncet, I., and Takacs, E. 1962. Biochemical studies on experimental congenital malformations: flavin nucleotides and folic acid in fetuses and livers from normal and riboflavin-deficient rats, J. Biol. Chem. 237:968–973.Google Scholar
  71. 71.
    Mookerjea, S., and Hawkins, W. W. 1960. Some anabolic aspects of protein metabolism in riboflavin deficiency in the rat, Brit. J. Nutr. 14:231–238.CrossRefGoogle Scholar
  72. 72.
    Mookerjea, S., and Jamdar, S. C. 1962. Liver transaminase activity in riboflavin-deficient rats, Canad. J. Biochem. Physiol. 40:1065–1070.CrossRefGoogle Scholar
  73. 73.
    Moore, D. F. 1930. Partial loss of central acuity of vision for reading and for distance in school children and its possible association with food deficiency, West African Med. J. 4:46–48.Google Scholar
  74. 74.
    Moore, D. F. 1939. Retrobulbar neuritis c pellagra in Nigeria, J. Trop. Med. Hyg. 42:109–114.Google Scholar
  75. 75.
    Morris, H. P., and Robertson, W. V. B. 1943. Growth rate and number of spontaneous mammary carcinomas and riboflavin concentration of liver, muscle, and tumor of C3H mice as influenced by dietary riboflavin, J. Natl. Cancer Inst. 3:479–489.Google Scholar
  76. 76.
    Moussa B., Youdim, H., and Sourkes, T. L. 1965. The effect of heat inhibitors and riboflavin deficiency on monoamine oxidase, Canad. J. Biochem. 43:1305–1318.CrossRefGoogle Scholar
  77. 77.
    Nutrition Reviews. 1945. “Vitamins in the therapy of shock and anoxia” 3:89–91, Nutrition Foundation, Inc., New York.Google Scholar
  78. 78.
    Pandit, V. I., and Chakrabarti, C. H. 1970. Effect of vitamin Bland B 2 avitaminosis on certain hepatic enzyme activities and protein biosynthesis in rats, Enzymologia 39:111–119.Google Scholar
  79. 79.
    Pandit, V. I., and Chakrabarti, C. H. 1970. In vitro incorporation of 14C serine into proteins of crude liver microsomal fraction of riboflavin deficient rats, Indian J. Exptl. Biol. 8:89–91.Google Scholar
  80. 80.
    Parsons, H. T. 1944. Further studies on human requirements for riboflavin, Fed. Proc. 3:162.Google Scholar
  81. 81.
    Pett, L. B., and Hanley, F. W. 1947. A nutrition survey among school children in British Columbia and Saskatchewan, Canad. Med. Assoc. J. 56:187–192.Google Scholar
  82. 82.
    Phillips, P. H., and Engel, R. W. 1938. Neuromalacia, its occurrence and histopathology in the chick on low riboflavin diets, Poultry Science 17:444.Google Scholar
  83. 83.
    Pollack, H., and Bookman, J. J. 1951. Riboflavin excretion as a function of protein metabolism in the normal, catabolic and diabetic human being, J. Lab. Clin. Med. 38:561–573.Google Scholar
  84. 84.
    Rivlin, R. S. 1970. Riboflavin metabolism, New Eng. J. Med. 283:463–472.CrossRefGoogle Scholar
  85. 85.
    Rivlin, R. S., Menendez, C., and Langdon, R. G. 1968. Biochemical similarities between hypothyroidism and riboflavin deficiency, Endocrinology 83:461–469.CrossRefGoogle Scholar
  86. 86.
    Sauberlich, H. E., Judd, J. H., Jr., Nichoalds, G. E., Broquist, H. P., and Darby, W. J. 1972. Application of the erythrocyte glutathione reductase assay in evaluating riboflavin nutritional status in a high school student population, Amer. J. Clin. Nutr. 25:756–762.Google Scholar
  87. 87.
    Scott, H. H. 1918. An investigation into an acute outbreak of “central neuritis,” Ann. Trop. Med. Parasitol. 12:109–196.Google Scholar
  88. 88.
    Sebrell, W. H. 1929. Fatty degeneration of the liver and kidneys in the dog apparently associated with diet, U.S. Publ. Health Rept. 44:2697–2701.Google Scholar
  89. 89.
    Sebrell, W. H., and Onstott, R. H. 1938. Riboflavin deficiency in dogs, Public Health Rept. 53:83.Google Scholar
  90. 90.
    Sebrell, W. H., and Butler, R. E. 1938. Riboflavin deficiency in man; a preliminary note, U.S. Public Health Rept. 53:2282–2284.Google Scholar
  91. 91.
    Sebrell, W. H., and Butler, R. E. 1939. Riboflavin deficiency in man (ariboflavinosis), U.S. Public Health Rept. 54:2121–2131.Google Scholar
  92. 92.
    Singher, H. O., Kensler, C. J., Taylor, H. C., Jr., Rhoads, C. P., and Unna, K. 1944. The effect of vitamin deficiency on estradiol inactivation by liver, J. Biol. Chem. 154:79–86.Google Scholar
  93. 93.
    Smith, J. M., Lu, S. D. C., Hare, A., Dick, E., and Daniels, M. 1959. The effect of nitrogen intake upon the urinary riboflavin excretion of young male adults, J. Nutr. 69:85–94.Google Scholar
  94. 94.
    Spector, H., Maass, A. R., Michaud, L., Elvehjem, C. A., and Hart, E. B. 1943. The role of riboflavin in blood regeneration. J. Biol. Chem. 150:75–87.Google Scholar
  95. 95.
    Spies, T. D., Bean, W. B., and Ashe, W. F. 1939. Recent advances in the treatment of pellagra and associated deficiencies, Ann. Intern. Med. 12:1830–1844.Google Scholar
  96. 96.
    Stannus, H. S. 1912. Pellagra in Nyasaland, Trans. Roy. Soc. Trop. Med. Hyg. 5:112–119.CrossRefGoogle Scholar
  97. 97.
    Stoerk, H. C., and Emerson, G. A. 1949. Complete regression of lymphosarcoma implants following temporary induction of riboflavin deficiency in mice, Proc. Soc. Exptl. Biol. Med. 70:703–704.Google Scholar
  98. 98.
    Street, H. R., Cowgill, G. R., and Zimmerman, H. M. 1941. Further observations of riboflavin deficiency in the dog, J. Nutr. 22:7–24.Google Scholar
  99. 99.
    Sugioka, G., Porta, E. A., Corey, P. N., and Hartroft, W. S. 1969. The liver of rats fed riboflavin-deficient diets at two levels of protein, Amer. J. Pathol. 54:1–19.Google Scholar
  100. 100.
    Sydenstricker, V. P. 1941. Clinical manifestations of ariboflavinosis, Amer. J. Public Health 31:344–350.CrossRefGoogle Scholar
  101. 101.
    Sydenstricker, V. P., Sebrell, W. H., Cleckley, H. M., and Kruse, H. D. 1940. The ocular manifestations of ariboflavinosis; a progress note. J. Amer. Med. Assoc. 114:2437–2445.Google Scholar
  102. 102.
    Sydenstricker, V. P., Geeslin, L. E., Templeton, C. M., and Weaver, J. W. 1939. Riboflavin deficiency in human subjects, J. Amer. Med. Assoc. 113:1697–1700.Google Scholar
  103. 103.
    Tandler, B., Erlandson, R. A., and Wynder, E. L. 1968. Riboflavin and mouse hepatic cell structure and function. 1. Ultrastructural alterations in simple deficiency, Amer. J. Pathol. 52:69–95.Google Scholar
  104. 104.
    Ten-State Nutrition Survey 1968–70. 1972. DHEW Publication No. (HSM) 72–8131, Department of Health, Education and Welfare, Washington, D.C.Google Scholar
  105. 105.
    Terrill, S. W., Ammerman, C. B., Walker, D. E., Edwards, R. M., Norton, H. W., and Becker, D. E. 1955. Riboflavin studies with pigs, J. Animal Sci. 14:593.Google Scholar
  106. 106.
    U.S. Interdepartmental Committee on Nutrition for National Defense. 1963. Manual for “Nutrition Surveys,” 2d ed., Superintendent of Documents, U.S. Government Printing Office, Washington, D.C.Google Scholar
  107. 107.
    Wada, H., and Snell, E. E. The enzymatic oxidation of pyridoxine and pyridoxamine phosphates. 1961. J. Biol. Chem. 236:2089–2095.Google Scholar
  108. 108.
    Warkany, J., and Schraffenberger, E. 1944. Congenital malformations enduced in rats by maternal nutritional deficiency. VI. The preventive factor, J. Nutr. 27:477.Google Scholar
  109. 109.
    Wiese, A. C., Johnson, B. C., Mitchell, H. H., and Nevens, W. B. 1947. Riboflavin deficiency in the dairy calf, J. Nutr. 33:263.Google Scholar
  110. 110.
    Williams, M. A., McIntosh, D. J., Hincenbergs, I. U., and Tamai, K. T. 1967. Comparative effects of pyridoxine, riboflavin and thiamine on linoleate utilization in rats, Biochem. Biophys. Acta. 137:388–390.Google Scholar
  111. 111.
    Wintrobe, M. M., Buschke, W., Follis, R. H., and Humphreys, S. 1944. Riboflavin deficiency in swine, Bull. Johns Hopkins Hosp. 75:102.Google Scholar
  112. 112.
    Wooley, J. G., and Sebrell, W. H. 1942. Nutritional deficiency and infection, Public Health Rept. 57:149.Google Scholar

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© Plenum Press, New York 1975

Authors and Affiliations

  • Grace A. Goldsmith
    • 1
  1. 1.School of Public Health and Tropical MedicineTulane University School of MedicineNew OrleansUSA

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