Regulatory Cells in the Bone Marrow

  • S. Adler
  • S. K. Singhal
  • E. E. Sercarz


Regulation of the immune system has been attributed primarily to thymus-derived T cells (1,2). Here we present evidence that suppression can be mediated by another cell type, found in the bone marrow, that is neither a T cell nor a macrophage. Others have also shown that bone marrow-derived (B) cell suppression can inhibit both humoral and cell-mediated immunity (3–6).


Bone Marrow Cell Spleen Cell Plaque Form Cell Spleen Cell Culture Adherent Bone Marrow Cell 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • S. Adler
    • 1
  • S. K. Singhal
    • 2
  • E. E. Sercarz
    • 1
  1. 1.Department of BacteriologyUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Bacteriology and ImmunologyUniversity of Western OntarioLondonCanada

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