Ontogeny of T Cell Function in the Fetal Lamb
The maturation of the ability of mammalian fetuses to mount active immunologic responses following antigen stimulus appears to follow a well-defined and precisely timed sequence. Competence to respond to some antigens arises very early in gestation, while other antigens are unable to stimulate active immune responses until later in gestation or even during the neonatal period. Thus, for each species or inbred strain, the earliest appearance of antibody formation to a given antigen, or of such other phenomena as allograft rejection, appears to representa very discrete differentiative event. It would also seem clear that this type of stepwise immunologic maturation is based upon a series of individual developmental events, rather than the abrupt appearance of a single general immunologic control mechanism. The apparently general nature of this sequential maturation of immunologic competence is supported by data in such disparate species as the fetal lamb (1, 2), the opossum (3), and the mouse (4).
KeywordsAllograft Rejection Diphtheria Toxoid Dinitro Phenyl Specific Helper Fetal Lamb
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