Immunosuppression by Fetal Liver as a Model for Tolerance to Self

  • Tehila Umiel


The nature of self tolerance is a complex phenomenon which as yet is poorly understood. Two major hypotheses have been formulated to explain the establishment of natural tolerance. The original hypothesis suggests that natural tolerance is acquired by elimination of specifically reactive cells (1). The alternative hypothesis suggests a mechanism whereby immunocompetent cells with potential to react against “self” exists, but are prevented from reactivity by inhibitory systems (2–7).


Spleen Cell Fetal Liver Suppressor Cell Immunocompetent Cell Mixed Lymphocyte Culture 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Tehila Umiel
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael

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