Immunosuppression by Fetal Liver as a Model for Tolerance to Self
The nature of self tolerance is a complex phenomenon which as yet is poorly understood. Two major hypotheses have been formulated to explain the establishment of natural tolerance. The original hypothesis suggests that natural tolerance is acquired by elimination of specifically reactive cells (1). The alternative hypothesis suggests a mechanism whereby immunocompetent cells with potential to react against “self” exists, but are prevented from reactivity by inhibitory systems (2–7).
KeywordsSpleen Cell Fetal Liver Suppressor Cell Immunocompetent Cell Mixed Lymphocyte Culture
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