A Model for Genetic Control of the Immune Response
From our work, and that of Benacerraf and colleagues, it seems reasonable to expect that at least two genes linked to the major histo-compatibility locus will be found to determine the response levels to each thymus dependent antigen. Our experiments take these findings further by defining the mode of action of the genes and their products. Thus, one type of Ir gene codes for the antigen-specific T cell regulators of the immune response, and thus, by inference, the T cell antigen recognition system. The second type of gene, by coding for an acceptor for the T cell regulators on lymphocytes, determines the ultimate response of the cell to antigen (Fig. 1).
KeywordsGenetic Control Cell Regulator Factor Class Mune Response Immune Response Gene
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