Overcoming Ir Gene Control of the Response to the Lysozymes
In studying the genetics of immune response capacity, it is of importance to work in a molecular system in which it might be possible to obtain knowledge of the exact antigenic determinant(s) under the genetic influence. It was with this in mind that synthetic, random polypeptides were first used in genetic studies (1), since it was assumed that these polymers had simpler structure than the average multideterminant antigen. Recent evidence (e.g. 2,3) clearly suggests that there are multiple unknown specificities in an antigen such as (T, G,)-A—L, making precise analysis difficult.
KeywordsPopliteal Lymph Node Hind Footpad Complex Control System Adoptive Transfer Study Peripheral Priming
Unable to display preview. Download preview PDF.
- 2.Rüde, E., and Günther, E., In ‘Progress in Immunology, II’ edited by L. Brent and J. Holborow, Elsevier, New York, p. 223, 1974.Google Scholar
- 5.Gershon, R.K., In‘Immunological Tolerance’ edited by D. H. Katz and B. Benacerraf, Academic Press, New York, p. 413, 1974.Google Scholar
- 6Eardley, D.D. and Sercarz, E.E., Submitted for publication.Google Scholar