Advertisement

T Helpers may be Sensitized by Antigen-Specifically Altered Structures, which are Coded by the I Region of the H-2 Gene Complex

  • R. M. Zinkernagel

Abstract

We have shown that virus immune cytotoxic cells are specific for virus-altered structures (1–4). These structures are coded for in the H-2K or the H-2D. Accordingly, virus immune cytotoxic CBA/H (H-2k) T cells sensitized in vivo will react in vitro only with ‘altere’ H-2k, not with ‘altere’ H-2d. The alteration can be envisaged as biochemical modifications of the protein or carbohydrate part of the private specificity of major transplantation antigens or of structures coded very closely to them. Alternatively, it could be formation of a complex of these structures and viral antigens (1–4). Structures coded for in the I region of the H-2 complex could not be shown to be relevant at the effector level (2, 3). However, this H-2 region may be involved in the initial sensitization and/or proliferation step(s). The requirement for compatibility at H-2K or H-2D of in vitro T cell-mediated cytotoxicity against virus infected target cells is apparently not due to an inherent incapacity of these T cells to interact with allogeneic infected target cells.

Keywords

51Cr Release Biochemical Modification Altered Structure Private Specificity Infected Target Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Zinkernagel, R. M., Doherty, P.C. Nature 1974, 248:701; 251:547; J. exp Med. 1975, 141:1427.PubMedCrossRefGoogle Scholar
  2. 2.
    Doherty, P.C., Zinkernagel, R.M. Transplant. Rev. 1974, 19:89; J. exp. Med. 1975, 141:502; Lancet (in press), and personal communication.PubMedGoogle Scholar
  3. 3.
    Blanden, R. V., Doherty, P.C., Dunlop, M. B. C., Gardner, I.D., Zinkernagel, R. M. and David, C. S. Nature 1975, 254:269, and unpublished results; personal communication.PubMedCrossRefGoogle Scholar
  4. 4.
    Zinkernagel, R.M. Nature 1974, 251:230; Ph. D. Thesis, Australian National University 1975.PubMedCrossRefGoogle Scholar
  5. 5.
    Katz, D.H., Hamaoka, T., Dorf, M. E., Benacerraf, B. Proc. Natl. Acad. Sci. U. S. A. 1973, 70:2624.PubMedCrossRefGoogle Scholar
  6. 6.
    Katz, D.H., Benacerraf, B. Transplant. Rev. 1975, 22: 175.PubMedGoogle Scholar
  7. 7.
    Erb, P., Feldmann, M. J. exp. Med. 1975, in press.Google Scholar
  8. 8.
    Miller, J. F. A. P., personal communicationGoogle Scholar
  9. 9.
    Shearer, G. M. Eur. J. Immunol. 1974, 4:527.Google Scholar
  10. 10.
    Cantor, H., Boyse, E. A. J. exp. Med. 1975, 141:1376, 1390.Google Scholar
  11. 11.
    Bretscher, P.A., personal communications.Google Scholar
  12. 12.
    Lafferty, K.J., Cunningham, A.J., Austr. J. exp. Biol. Med. Sci. 1975, 53:27.CrossRefGoogle Scholar
  13. 13.
    Lafferty, K. J., Misko, I. S. and Cooley, M.A. Nature 1974, 249: 275.PubMedCrossRefGoogle Scholar
  14. 14.
    Bechtol, K.B., Wegmann, T. G., Freed, J. H., Brumet, F. C., Chesebro, B. W., Herzenberg, L. A., Mevitt, H. O. Cell. Immunol. 1974, 13:264.PubMedCrossRefGoogle Scholar
  15. 15.
    Pilarski, L., personal communications.Google Scholar
  16. 16.
    Von Boehmer, H., personal communicationGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. M. Zinkernagel
    • 1
  1. 1.Department of MicrobiologyJohn Curtin School of Medical ResearchCanberraAustralia

Personalised recommendations