Tumor Immunology—Interaction between Lymphocytes, Antibodies and Neoplastic Cells: A Summary
There are great expectations for tumor immunology in the belief that it will provide more alternatives to clinicians in the management and control of neoplasia. This is due to the fact that the immunologic approach to the elimination of total tumor burden offers the aspect of specificity that other therapeutic modalities lack at the present time. Since cancer is a systemic disease and since the intrinsic aggressiveness of tumor cells varies not only among different classes of tumors but also tumors of similar histologic type, the commonality of the tumor cell surface is a major prospect for immunotherapy. Currently, one of the major questions concerning tumor immunologists is the ability of antigenic tumors to develop and the nature of the immune status of the host against its own primary tumor. Reasonable estimates are that not more than 10% of human cancer is associated with viruses, and less than 5% is associated with radiation. The increasing percentage of spontaneous cancers in man, especially lung cancer, is associated with combinations of environmental factors, presumably in the form of chemical and physical carcinogens. Thus, information about the success of antigenic tumors should continue to be developed from models based on various modes of carcinogenesis.
KeywordsOncogenic Virus Tumor Immunology Host Control Total Tumor Burden Spontaneous Cancer
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