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The Presence of Cells Expressing Immune-Complex Receptors in Non-Lymphoid Murine Tumors

  • Gary R. Braslawsky
  • Margalith Yaakubowicz
  • Asher Frensdorff
  • Isaac P. Witz

Abstract

Tumor cells, whether of lymphoid or non-lymphoid origin, are coated in vivo with a surface layer of immunoglobulin (Ig) (1). At least some of this surface Ig may represent anti tumor antibody (1,2) that is most likely attached to the surface through the Fab portion of the molecule. However, there have been reports that some non-lymphoid tumors contain cells which bear an Fc or Fc-like receptor (3–5,11). The Ig-coat of these Fc-reactive cells could contain anti tumor antibodies, as well as non-tumor antibodies, attached to the surface through the Fc part of the molecule (most likely as immune complex). In this paper we present evidence that non-lymphoid tumor populations can fix both in vivo and in vitro tumor unrelated antibodies or immune complexes.

Keywords

Immune Complex Tumor Cell Population Control Animal Group Soluble Immune Complex Anti Tumor Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Gary R. Braslawsky
    • 1
  • Margalith Yaakubowicz
    • 1
  • Asher Frensdorff
    • 1
  • Isaac P. Witz
    • 1
  1. 1.Department of Microbiology, The George S. Wise Center for Life SciencesTel Aviv UniversityTel AvivIsrael

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