Tumor cells, whether of lymphoid or non-lymphoid origin, are coated in vivo with a surface layer of immunoglobulin (Ig) (1). At least some of this surface Ig may represent anti tumor antibody (1,2) that is most likely attached to the surface through the Fab portion of the molecule. However, there have been reports that some non-lymphoid tumors contain cells which bear an Fc or Fc-like receptor (3–5,11). The Ig-coat of these Fc-reactive cells could contain anti tumor antibodies, as well as non-tumor antibodies, attached to the surface through the Fc part of the molecule (most likely as immune complex). In this paper we present evidence that non-lymphoid tumor populations can fix both in vivo and in vitro tumor unrelated antibodies or immune complexes.
Immune Complex Tumor Cell Population Control Animal Group Soluble Immune Complex Anti Tumor Antibody
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