A New T Cell Neoplasm Expressing Surface Anti-DNP Activity, Developed from the Thymus of Mice Bearing MOPC-315 Plasma Cell Tumors
The plasmacytoma of BALB/c mouse has become an important model for the study of some clinical and immunochemical aspects of human multiple myeloma. The characteristics of multiple myeloma is the high level of monoclonal immunoglobulin (Ig) accompanied by diminished production of all classes of Ig and by immunological deficiency consisting mainly of the primary response to antigen (1,2,3). Yakulis et al have demonstrated that upon implantation of plasmacytoma into normal BALB/c mice a large percentage of circulating lymphocytes aquired on their surface the idiotypic specificity of the Ig produced by the plasmacytoma (4). This phenomenon could be reproduced in-vitro by incubating normal lymphocytes with an RNA preparation from the plasmacytoma (5).
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