Macrophage Killing Capacity. Aspects of Mechanism
The heterogeneity of effector cells and killing mechanisms against normal and tumor allografts has been frequently emphasized. It is generally believed that rejection of foreign graft tissue is mediated mostly by cellular immune mechanisms where the T derived lymphocytes are the most important cells which recognize and lyse foreign target cells. However, during the last few years, evidence has been accumulating demonstrating the participation of macrophages in graft rejection and tumor destruction (Reviewed by Nelson (1)). In vitro studies have shown that isolated immune macrophages were cytotoxic to tumor cells bearing alloantigens used for immunization (2,3). However, the mechanism by which macrophages gain their cytotoxic capacity as well as their killing mechansim is still far from clear.
KeywordsCationized Ferritin Cytotoxic Capacity Normal Macrophage Macrophage Cytotoxicity Immune Spleen Cell
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