Divalent Cation Requirements as a Tool for the Study of Cell-Mediated Cytotoxicity Systems
Cells mediating cytolysis of other cells in vitro can be classified into two broad classes, namely T cells (sensitised thymus derived cells lysing the relevant target cells, which they recognise through specific cell surface receptors) and non-T cells (unsensitised cells, not thymus-derived, lysing antibody-coated target cells which they recognise through cell surface Fc receptors). Cytolytic non-T cell populations are ill-defined as to their exact identity, and moreover, are very probably heterogeneous. The mechanism of lysis can be divided into at least three stages: recognition, post-recognition hit, and target cell disintegration which can occur in the absence of effector cells. The physiology of the post-recognition hit stage is unknown, and moreover, may be different from one type of cytolysis to the other.
KeywordsEffector Cell Mouse Spleen Cell Specific Cell Surface Receptor Cation Requirement Normal Peripheral Human Blood
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