Immunological Potential of Yolk Sac Cells

  • F. Hofman
  • A. Globerson


Yolk sac cells have been shown to be the source of hemopoietic cells in the embryo (1) and to provide lymphoid precursor cells to the thymus (2), bursa of Fabricius (3) and embryonic liver (4). Accordingly, study of the ontogeny of the immune response should begin with analysis of the yolk sac cells. The questions raised in this respect are whether at this early stage of development the cells already have the potential to produce immune responses, and whether they can express such a potential. Answering this may advance the understanding of the generation of diversity.


Mixed Lymphocyte Culture Embryonic Liver Local Lymph Node Assay Immunological Potential Embryonic Thymus 
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  1. 1.
    Kirschbaum, K. and H. Downey, Anat. Rec. 68, 227 (1937)CrossRefGoogle Scholar
  2. 2.
    Moore, M. A. S. and J. J. T. Owen, J. Exp. Med. 126, 715 (1967)PubMedCrossRefGoogle Scholar
  3. 3.
    Moore, M. A. S. and J. J. T. Owen, Nature 215, 1081 (1967)PubMedCrossRefGoogle Scholar
  4. 4.
    Moore, M. A. S. and D. Metcalf, Brit. J. Hematol. 18, 279 (1970)CrossRefGoogle Scholar
  5. 5.
    Tyan, M. L., J. Immunol. 100, 535 (1968)PubMedGoogle Scholar
  6. 6.
    Auerbach, R. and A. Globerson, Exp. Cell Res. 42, 31 (1966)PubMedCrossRefGoogle Scholar
  7. 7.
    Hofman, F. and A. Globerson, Eur. J. Immunol. 3, 179 (1973)CrossRefGoogle Scholar
  8. 8.
    Cantor, H. and R. Assofsky, J. Exp. Med. 135, 764 (1972)PubMedCrossRefGoogle Scholar
  9. 9.
    Arrenbrecht, S., submitted.Google Scholar
  10. 10.
    Hofman, F., unpublished observations.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • F. Hofman
    • 1
  • A. Globerson
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael

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