Rat Anti-Lymphocyte Alloantibodies Block Con A-Stimulation of T Lymphocytes: Inhibition of a Polyclonally Specific T Cell Reaction

  • Hartmut Wekerle


Alloantisera induced in rats by immunization against allogeneic lymphocytes contain antibodies that prevent non-sensitized, immunologically competent T lymphocytes from recognizing foreign cellular antigen. Absorption of such blocking antisera on various tissues combined with immunogenetic analyses revealed that these blocking antibodies act by binding to a constant part of the T cell receptor, which is a non-SD product of the major histocompatibility gene locus (1).


Memory Cell Blast Cell Constant Part Mixed Lymphocyte Culture ConA Stimulation 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Hartmut Wekerle
    • 1
  1. 1.Max-Planck-Institut für ImmunbiologieFreiburgGermany

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