Rat Anti-Lymphocyte Alloantibodies Block Con A-Stimulation of T Lymphocytes: Inhibition of a Polyclonally Specific T Cell Reaction
Alloantisera induced in rats by immunization against allogeneic lymphocytes contain antibodies that prevent non-sensitized, immunologically competent T lymphocytes from recognizing foreign cellular antigen. Absorption of such blocking antisera on various tissues combined with immunogenetic analyses revealed that these blocking antibodies act by binding to a constant part of the T cell receptor, which is a non-SD product of the major histocompatibility gene locus (1).
KeywordsMemory Cell Blast Cell Constant Part Mixed Lymphocyte Culture ConA Stimulation
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