Characterization and Specificity of a T-Cell Cooperative Factor
One of the central problems in analyzing immune response phenomena, is the mechanism of thymus (T)-bone marrow (B) derived cell interactions. Investigations performed in the past few years resulted in the identification and characterization of various biologically active mediators produced by T cells which are capable of stimulating B cells. Some of these T cell factors have been shown to be antigen-specific (1–3) whereas others are non-specific (4,5), and their functional effects are either-enhancing (1–5) or suppressing (3) antibody production by B cells.
KeywordsAntibody Production Cooperative Activity Cell Supernatant Active Mediator Normal Rabbit Serum
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- 3.Tada, T. (1975) In Immune Recognition. Proceedings of the Ninth Leukocyte Culture Conference. A.S. Rosenthal, ed., Academic Press, New York, in press.Google Scholar
- 6.Taussig, M.J., Mozes, E. and Isac, R. (1974) J. Exp. Med. 140: 301.Google Scholar
- 7.Mozes, E., Isac, R. and Taussig, M.J. (1975) J. Exp. Med. 141: 703.Google Scholar
- 8.Mozes, E. (1974) Progr. Immunol. II Vol. 2, L. Brent and J. Holborow, eds., North—Holland Publishing Co., p. 191.Google Scholar
- 10.Taussig, M.J. and Munro, A.J. (1975) In Immune Recognition. Proceeding of the Ninth Leukocyte Culture Conference. A.S. Rosenthal, ed., Academic Press, New York, in press.Google Scholar