Virus-Immune Cytotoxic T Cells are Sentized to by Virus Specifically Altered Structures Coded for in H-2K or H-2D: A Biological Role for Major Histocompatibility Antigens

  • Rolf M. Zinkernagel
  • Peter C. Doherty


We discovered quite fortuitously that specific T cell-mediated lysis (51Cr release) of target cells (macrophages, tumor cells or fibroblasts) infected with lymphocytic choriomeningitis (LCM) virus occurs only if lymphocyte and target are compatible at the H-2 gene complex1,2. Experiments with ectromelia (mousepox)3 and paramyxovirus (Sendai)2 infection indicate that this may be a general phenomenon, as these three viruses differ considerably in their effects at the molecular level. This view is further reinforced by the demonstration, from other laboratories, that the same constraint applies in the cytotoxic T cell response to trinitrophenyl (TNP)-modified mouse lymphocytes4, and in Rous sarcoma virus infection of chickens5.


Evolutionary Advantage 51Cr Release Antigen Type Lymphocytic Choriomeningitis Recognition Structure 
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  1. 1.
    Zinkernagel, R.M., Doherty, P.C. Nature, 1974, 248, 701; 251, 547. J.exp.Med. 1975, 141, 1427.PubMedCrossRefGoogle Scholar
  2. 2.
    Doherty, P.C., Zinkernagel, R.M. Transplant.Rev. 1974, L9, 19. J.exp.Med. 1975, 141, 502. J.Immunol. 1975, 114, 30. Nature (in the press), Lancet (in the press). Unpublished data.Google Scholar
  3. 3.
    Gardner, I., Bowern, N.A., Blanden, R.V. Eur.J.Immunol. 1975, 5, 122.PubMedCrossRefGoogle Scholar
  4. 4.
    Shearer, G.M. Eur.J. Immunol. 1974, 4, 527.PubMedCrossRefGoogle Scholar
  5. 5.
    Wainberg, M.A., Markson, Y., Weiss, D.W., Doljanski, F. F.Proc.Natl.Acad.Sci. U.S.A. 1974, 71, 3565.Google Scholar
  6. 6.
    Blanden, R.V., Doherty, P.C., Dunlop, M.B.C., Gardner, I.D., Zinkernagel, R.M., David, C.S. Nature, 1975, 254, 269.PubMedCrossRefGoogle Scholar
  7. Blanden, R.V., Bowern, N.A., Pang, T.E., Gardner, I.D., Parish, C.R. (in the press).Google Scholar
  8. 8.
    Zinkernagel, R.M. Nature, 1974, 251, 230; Ph.D Thesis, Australian National University, 1975.Google Scholar
  9. 9.
    Katz, D.H., Hamaoka, T., Dorf, M.E., Benacerraf, B. Proc. Natl.Acad.Sci U.S.A. 1974, 70, 2624.Google Scholar
  10. 10.
    Shevach, E.M., Rosenthal, A.S. J.exp.Med. 1973, 138, 1213.PubMedCrossRefGoogle Scholar
  11. 11.
    Bevan, M.J. J. Immunol. 1975, 114, 317.Google Scholar
  12. 12.
    Lindahl, F.F., Bach, F.H. Nature, 1975, 254, 607.PubMedCrossRefGoogle Scholar
  13. 13.
    Burnet, F.M. Nature, 1973, 245, 359.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Rolf M. Zinkernagel
    • 1
  • Peter C. Doherty
    • 1
  1. 1.Department of Microbiology, The John Curtin School of Medical ResearchA.N.U.CanberraAustralia

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