The Influence of “I” Region Antibodies on Transplants
The role of antibody in graft rejection is a vexed question. There are many reports of graft rejection apparently mediated by antibody but equally antibody clearly has protective effects under some circumstances. One has not been able to predict with total assurance the outcome of exposing a transplant to an antiserum directed against it. Clearly this multiparametric situation is amenable to analysis and it is desirable to do so because passive enhancement, by which we mean the prolongation of graft survival by passively administered antigraft antiserum, is the one tangible hope at the present for generating donor-specific immunosuppression in transplantation. The inadequacies of drug and ALS therapy and the total failure to achieve transplant tolerance in adults makes this analysis all the more pressing.
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