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Bursa of Fabricius: Uptake of Radioactive Particles and Radiotoxic “Sealing” of Bursal Follicles

  • T. Schaffner
  • J. Herring
  • H. Gerber
  • H. Cottier

Abstract

Earlier studies have demonstrated that the avian bursa functions as a site of intense and selective uptake of particles through the tuft epithelium which overlies the follicles (l, 2). The bursa undergoes rhythmic compression in synchrony with respiration and shows slow, peristalsis-like movements which, in addition to a suction reflex elicited by contact of fluids or solids with the anal orifice, provides for a constant exchange of cloacal and bursal contents. These findings and indirect evidence in favor of bacterial mechanisms located in the tuft epithelial covering the bursal follicles (2) led to the postulate that the bursa may be primarily an immunologic contact organ where lymphoid cells become sensitized against intestinal antigens (3). The above observations have been confirmed and extended by other authors (4).

Keywords

Organ Dose Peroral Administration Radioactive Particle Lower Serum Concen Estimate Organ Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schaffner, Th., Sordat, B., Mueller, J., Miller, G.G., Hess, M.W. and Cottier, H. Abstract, Joint Meeting of European Socie ties for Immunology, Strasbourg, September 4–7, 1973, P 68.Google Scholar
  2. 2.
    Schaffher, Th., Mueller, J., Hess, M.W., Cottier, H., Sordat, B and Röpke, C. Cellular Immunology, 13, 304 (1974).CrossRefGoogle Scholar
  3. 3.
    Schaffner, Th., Hess, M.W. and Cottier, H. Ser. Haemat., VII,4 (1914).Google Scholar
  4. 4.
    Sorvari, T., Sorvari, R., Ruotsalainen, P., Toivanen, A., and Toivanen, P. Nature, 253, 217 (1975).PubMedCrossRefGoogle Scholar
  5. 5.
    Ockenden, D.W. and Welch, G.A. J. ehem. Soc. 3358 (1956).Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • T. Schaffner
    • 1
  • J. Herring
    • 2
  • H. Gerber
    • 1
  • H. Cottier
    • 1
  1. 1.Institute of PathologyUniversity of BernSwitzerland
  2. 2.Biology DepartmentBattelle Pacific Northwest LaboratoriesRichlandUSA

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