Interference of Cyclophosphamide with the Development of T Helper Activity in Rabbits
In rats antibody formation against Brucella was suppressed by a single injection of cyclophosphamide given between 1 day before and 4 days after antigenic stimulation (1). A selective suppression of 7S antibody synthesis was described in rats immunized with Sheep Red Blood Cells (SRBC) after treatment with a course of 5 daily injections of cyclophosphamide, started 2 days after antigen injection (2). In mice a cyclophosphamide induced immunological tolerance to SRBC was found when the drug was given simultaneously with or 2 days after antigen injection (3.4). In most of these systems, coöperation between T and B cells is required for antibody production. In rats (5), guinea pigs (6) and rabbits (7) the histological changes caused by a single injection of cyclophosphamide were described. In all species cells homing in the non-thymus-dependent area’s of spleen and lymph nodes proved to be sensitive to the drug.
KeywordsMemory Cell Antigenic Stimulation Antigen Injection Accelerate Response Stimulate Lymph Node
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