Interference of Cyclophosphamide with the Development of T Helper Activity in Rabbits

  • A. A. van den Broek
  • G. H. Blijham


In rats antibody formation against Brucella was suppressed by a single injection of cyclophosphamide given between 1 day before and 4 days after antigenic stimulation (1). A selective suppression of 7S antibody synthesis was described in rats immunized with Sheep Red Blood Cells (SRBC) after treatment with a course of 5 daily injections of cyclophosphamide, started 2 days after antigen injection (2). In mice a cyclophosphamide induced immunological tolerance to SRBC was found when the drug was given simultaneously with or 2 days after antigen injection (3.4). In most of these systems, coöperation between T and B cells is required for antibody production. In rats (5), guinea pigs (6) and rabbits (7) the histological changes caused by a single injection of cyclophosphamide were described. In all species cells homing in the non-thymus-dependent area’s of spleen and lymph nodes proved to be sensitive to the drug.


Memory Cell Antigenic Stimulation Antigen Injection Accelerate Response Stimulate Lymph Node 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • A. A. van den Broek
  • G. H. Blijham
    • 1
  1. 1.Department of HistologyUniversity of GroningenGroningenThe Netherlands

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