Effector Cell Requirements for Antibody-Dependent and Mitogen-Induced Cytotoxicity
The generation and characterization of cytotoxic effector cells has been studied in several laboratories using a variety of xenogeneic, allogeneic and syngeneic systems (1–3). We have attempted to characterize the cell requirements for cytotoxic effector function in man in two independent assays, cytotoxic activity of non-immune effector cells for antibody-coated target cells and cytotoxic activity for target cells in the presence of mitogen. It has been suggested by several groups that antibody-dependent cytotoxicity (ADC) reflects the functional activity of B-lymphocytes whereas T-lymphocytes are active in mitogen-induced cytotoxicity (MIC) (1–4). Our earlier studies in rabbit suggested that the predominant effector cell in ADC was of monocyte-macrophage origin rather than a B-cell (5–7) and this has also been shown to be the case in mouse (8).
KeywordsEffector Cell Common Variable Immunodeficiency Peritoneal Exudate Cell Severe Combine Immunodeficiency Disease Cytotoxic Effector Cell
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- 2.MacLennan, I.C.M., Transpl. Rev. 13: 67, 1972.Google Scholar
- 3.Perlmann, P., Perlmann, H. and Wigzell, H., Transpl. Rev. 13: 91, 1972.Google Scholar
- 4.VanBoxel, J.A., Paul, W.E., Frank, M.M. and Green, I., J. Immunol. 110: 1027, 1973.Google Scholar
- 10.Gelfand, E.W., Biggar, W.D. and Orange, R.P. Ped. Clin. N. Amer. 21: 745, 1974.Google Scholar
- 12.Perlmann, P. and Maennan, I.C.M., Progress in Immunology II, 3: 347, 1947Google Scholar