Effector Cell Requirements for Antibody-Dependent and Mitogen-Induced Cytotoxicity

  • Erwin W. Gelfand


The generation and characterization of cytotoxic effector cells has been studied in several laboratories using a variety of xenogeneic, allogeneic and syngeneic systems (1–3). We have attempted to characterize the cell requirements for cytotoxic effector function in man in two independent assays, cytotoxic activity of non-immune effector cells for antibody-coated target cells and cytotoxic activity for target cells in the presence of mitogen. It has been suggested by several groups that antibody-dependent cytotoxicity (ADC) reflects the functional activity of B-lymphocytes whereas T-lymphocytes are active in mitogen-induced cytotoxicity (MIC) (1–4). Our earlier studies in rabbit suggested that the predominant effector cell in ADC was of monocyte-macrophage origin rather than a B-cell (5–7) and this has also been shown to be the case in mouse (8).


Effector Cell Common Variable Immunodeficiency Peritoneal Exudate Cell Severe Combine Immunodeficiency Disease Cytotoxic Effector Cell 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Erwin W. Gelfand
    • 1
  1. 1.Department of ImmunologyThe Hospital For Sick ChildrenTorontoCanada

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