Cell Interaction in B/W Mice: A Reversible Defect at the T-Cell Level

  • John C. Roder
  • David A. Bell
  • Sharwan K. Singhal


There is abundant evidence showing that many T cell functions are impaired in overtly autoimmune New Zealand mice (reviewed in 1). An example of this is the age dependent decline in antibody responses to T dependent, but not T independent antigens which accompanies the spontaneous rise in auto antibody formation. It has been suggested (2, 3) that the antibody mediated autoimmune phenomena occurring in these mice may reflect an early loss of suppressor T cells and it would be expected that the increase in thymocytotoxic auto-antibody (4) would cause a reduction in T cells and hence a decline in T dependent antibody responses. Our studies examine the nature of the defect leading to a loss of responsiveness to SRBC and the results support our hypothesis (5) that in aging B/W mice there arises a suppressor of T cell activation which prevents the induction of T cell help and possibly T cell tolerance to self antigens.


Spleen Cell Suppressor Cell Reversible Defect Normal Mouse Serum Plaque Form Cell 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • John C. Roder
    • 1
  • David A. Bell
    • 1
  • Sharwan K. Singhal
    • 1
  1. 1.Depts. of Medicine, and Bacteriology and ImmunologyUniversity of Western OntarioLondonCanada

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