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Lymphoid Tissue Architecture. III. Germinal Centers, T Cells, and Thymus-Dependent vs Thymus-Independent Antigens

  • I. L. Weissman
  • G. A. Gutman
  • S. H. Friedberg
  • L. Jerabek

Abstract

Although the genesis and constituents of lymphoid tissue germinal centers are not clearly defined, there is evidence that they are induced by antigen, and may play a role in T-B cell cooperation (1–3), generation of immunological memory (4), and differentiation of antibody-forming cells (5–6). Since we had previously demonstrated T antigen positive cells as constituents of germinal centers, we wished to test their induction in “oligosynthetic” lymph nodes with defined antigens. We chose three classes of antigen — thymus dependent antigens, thymus-independent antigens which induce antibodies limited to the IgM class, and a newly-described thymus-independent antigen, DNP32- Ficoll, which induces both IgM and IgG antibodies.

Keywords

Germinal Center Popliteal Lymph Node Primary Follicle Secondary Follicle Cyanuric Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • I. L. Weissman
    • 1
  • G. A. Gutman
    • 1
  • S. H. Friedberg
    • 1
  • L. Jerabek
    • 1
  1. 1.Laboratory of Experimental Oncology, Dept. of PathologyStanford Medical SchoolUSA

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