Isolation and Partial Chemical Characterization of THF, A Thymus Hormone Involved in Immune Maturation of Lymphoid Cells

  • A. I. Kook
  • Y. Yakir
  • N. Trainin


Humoral factors of the thymus participate in the processes which lead to maturation and acquisition of immunocompetence of cells of the lymphoid system (1,2). We have demonstrated that THF, a thymic factor partially purified in our laboratory (3,4), induces immune maturation of thymus derived lymphoid cells via an obligatory rise in cellular levels of cAMP and in membranal adenyl cyclase activity (5,6). We have now isolated and partially characterized the chemical properties of THF with the aim to further understand the processes which lead to differentiation of thymus derived cells.


Spleen Cell Alcian Blue Anion Exchange Chromatography Column Sephadex Column Thymic Hormone 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • A. I. Kook
    • 1
  • Y. Yakir
    • 1
  • N. Trainin
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael

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