Abstract
Since it is known that destruction of the afferent lymph pathway can prevent the induction of contact sensitivity by skin painting the lymph must contain some essential element. In earlier experiments on pigs (McFarlin 1973) lymph was collected following skin painting with DNFB. Whole lymph was infused into an afferent lymphatic in a normal animal and shown to be capable of inducing contact sensitivity. In the experiments reported here pigs were painted with 50 microlitres of a 10% solution of DNFB in a mixture of equal parts of acetone and DMSO, a dose which was sufficient to sensitise the majority of animals.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Marlin, D.E. and Balfour, B.M., Immunology 25, 995 (1973).
Allan, D. and Crumpton, M.J., Biochem.J. 120, 133 (1970).
Balfour, B.M., Marlin, D.E., Sumerska, T. and Parker, D., Monogr.Allergy 8, 27 (1974)
Baumgarten, A. and Geczy, A.F., Immunology Lond. 19, 205 (1970).
Shearer, G.M., Rehn, T.G. and Garbarino, C.A., J.exp.Med. 141, 1348 (1975).
Dennert, G. and Haen, L.E., J. Immunol. 114, 1705 (1975).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Søeberg, B., Sumerska, T., Balfour, B.M. (1976). The Role of the Afferent Lymph in the Induction of Contact Sensitivity. In: Feldman, M., Globerson, A. (eds) Immune Reactivity of Lymphocytes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4355-4_29
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4355-4_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4357-8
Online ISBN: 978-1-4613-4355-4
eBook Packages: Springer Book Archive