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Human Lymphatic Microecology — Specificity, Characterization and Ontogeny of Different Reticulum Cells in the B Cell and T Cell Regions

  • H. K. Müller-Hermelink
  • U. Heusermann
  • E. Kaiserling
  • H.-J. Stutte

Abstract

The well-known phenomenon that the circulating B and T lymphocytes reach the lymphatic tissue by similar routes but dissociate thereafter according to their functional differentiation and localize at different sites, can hardly be understood if lymphocytes alone are considered as responsible. The evidence for specific microenvironments in the lymphatic tissue defining the structural component of a microecological relationship between migrating and resting cells, has been indirect and. up to now, a theoretical chalenge. The term “reticulum cell” is used as a common name for all structural cells in the lymphore-ticular tissue, in spite of the fact that 1) different functional definitions, that have been proposed, may determine different cell types (e.g. fiber formation vs. phagocytosis) and 2) new cell types have been described in the lymphatic tissue of rodents and man, which neither phagocytose nore form fibers. These cells have been called dendritic reticulum cells (DRC)(l) and intergitating reticulum cells (IDC) (2). Our study deals with the morphological demonstration of different structural (“reticulum”) cells in human lymphatic tissue, which as a micro-ecological pattern, may give a formal explanation for the different localization of T and B lymphocytes.

Keywords

Lymphatic Tissue Cell Region Acid Phosphatase Activity Reticulum Cell Nonspecific Esterase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    VELDMAN, J.E.: Histophysiology and electron microscopy of the immune response. N.V.Boekdrukkeij Dijks-tra Niemeyer, Groningen (1970)Google Scholar
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    DUKOR, P.; BIANCO, C.; NUSSENZWEIG, V.s Proc.Nat.Acad. Sci USA 67, 991 (1970)CrossRefGoogle Scholar
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    MüLLER-HERMELINK, H.K.; HEUSERMANN, U.; STUTTE, H.-J.: Cell.Tiss.Res. 154, 167 1974)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • H. K. Müller-Hermelink
    • 1
  • U. Heusermann
    • 1
  • E. Kaiserling
    • 1
  • H.-J. Stutte
    • 1
  1. 1.Dept. of PathologyUniv. of KielFed. Rep. Germany

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